Document Detail

Long-term safety and efficacy study of intranasal ipratropium bromide.
MedLine Citation:
PMID:  2139094     Owner:  NLM     Status:  MEDLINE    
Forty patients presenting with watery rhinorrhoea as their main complaint were entered in an open trial of long-term intranasal ipratropium bromide. Fourteen of these (35 per cent) found it to be beneficial and completed one year of treatment. Side-effects were seen in 28 patients (70 per cent) but these were local and mild in nature. All resolved during the trial as patients adjusted the dosage to individual severity and frequency of symptoms. No significant systemic effects were noted during the course of therapy. Ipratropium is a useful drug in the treatment of watery rhinorrhoea and appears safe for long-term use.
C A Milford; T A Mugliston; V J Lund; I S Mackay
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  104     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-5     Citation Subset:  AIM; IM    
ENT Department, Charing Cross Hospital, London.
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MeSH Terms
Administration, Intranasal
Atropine Derivatives / administration & dosage*
Clinical Trials as Topic
Epistaxis / chemically induced
Headache / chemically induced
Ipratropium / administration & dosage*,  adverse effects,  therapeutic use
Middle Aged
Nasal Mucosa / drug effects
Rhinitis / drug therapy*
Time Factors
Reg. No./Substance:
0/Atropine Derivatives; 60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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