Document Detail

Long-term results of topical mitomycin C 0.02% for primary and recurrent conjunctival-corneal intraepithelial neoplasia.
MedLine Citation:
PMID:  19617789     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy, recurrence rate, and long-term complications of topical mitomycin C (MMC) 0.02% for conjunctival-corneal intraepithelial neoplasia (CCIN). METHODS: A prospective, nonrandomized, noncontrolled study was conducted of patients with primary or recurrent CCIN treated with topical MMC 0.02%, four times per day, for 28 consecutive days. The main outcome measures were complete resolution of the neoplasia by slit-lamp examination and cytology 1 month after treatment, tumor recurrence, and long-term complications. RESULTS: Between June 1999 and September 2005, 23 patients were included. Eighteen had primary CCIN (group 1) and 5 had recurrent CCIN (group 2). The mean follow-up was 46 months in group 1 and 54 months in group 2. All patients were treated with MMC 0.02% for 28 consecutive days. Complete resolution of the lesion was achieved in all patients after 1 month of treatment. Recurrence occurred in 1 patient (4.3%) after 24 months of treatment. Four patients developed corneal erosion (17.4%), 2 of them with primary CCIN and 2 with recurrent CCIN. Corneal erosion occurred 4 to 24 months after treatment and was treated successfully. The probability for corneal erosions by the log-rank test was equal for both groups (p = 0.1705). CONCLUSIONS: The use of topical MMC 0.02% for 28 consecutive days to treat primary or recurrent CCIN was effective and showed a low recurrence rate. Corneal erosion occurred in 17.4% of cases and can occur as late as 24 months after treatment.
Priscilla L Ballalai; Clelia M Erwenne; Maria Cristina Martins; Marcia S Lowen; Jeison N Barros
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  25     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Antibiotics, Antineoplastic / administration & dosage*
Carcinoma in Situ / drug therapy*,  pathology
Conjunctival Neoplasms / drug therapy*,  pathology
Corneal Diseases / drug therapy*,  pathology
Dose-Response Relationship, Drug
Eye Neoplasms / drug therapy,  pathology
Follow-Up Studies
Middle Aged
Mitomycin / administration & dosage*
Neoplasm Recurrence, Local / drug therapy*,  pathology
Ophthalmic Solutions
Prospective Studies
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Ophthalmic Solutions; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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