Document Detail


Long-term results of repeated anti-vascular endothelial growth factor therapy in eyes with retinal pigment epithelial tears.
MedLine Citation:
PMID:  23023526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the long-term results of retinal pigment epithelium tears in eyes treated with repeated anti-vascular endothelial growth factor (VEGF) therapy.
METHODS: Five patients with retinal pigment epithelial tears (without foveal center involvement) after anti-VEGF injection were studied retrospectively. Mean follow-up time was 52 months, with measurements of visual acuity and evaluation of macular findings by angiography and optical coherence tomography during this period. All eyes had a persistent submacular neovascular membrane 30 days after the tear. An anti-VEGF drug was reinjected until the membranes stopped leaking.
RESULTS: The mean initial visual acuity immediately after the tear was 20/160, and the mean final visual acuity was 20/60. The number of anti-VEGF reinjections varied from two to eight during the follow-up period. Long-term optical coherence tomography analysis showed reduced fluid and remodeling of the torn retinal pigment epithelium.
CONCLUSION: Long-term visual results with repeated anti-VEGF therapy are not as devastating as suggested previously. Visual acuity and metamorphopsia improve with time as long as the neovascular membrane is inactive. Optical coherence tomography changes in the macular area reflect the visual acuity improvement.
Authors:
Carlos A Moreira; Luis A Arana; Rommel J Zago
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  33     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-05-09     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Affiliation:
Hospital de Olhos do Parana and Department of Ophthalmology, Universidade Federal do Parana, Curitiba, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angiogenesis Inhibitors / administration & dosage,  adverse effects,  therapeutic use*
Antibodies, Monoclonal, Humanized / administration & dosage,  adverse effects,  therapeutic use
Capillary Permeability / drug effects
Female
Fluorescein Angiography
Follow-Up Studies
Humans
Intravitreal Injections
Male
Middle Aged
Retinal Neovascularization / drug therapy*,  physiopathology
Retinal Perforations / drug therapy*,  etiology,  physiopathology
Retinal Pigment Epithelium / pathology*
Retreatment
Retrospective Studies
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A / antagonists & inhibitors*
Visual Acuity / physiology
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 0/ranibizumab; 2S9ZZM9Q9V/bevacizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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