Document Detail

Long-term results of a multicenter study on sacral nerve stimulation for treatment of urinary urge incontinence, urgency-frequency, and retention.
MedLine Citation:
PMID:  11114569     Owner:  NLM     Status:  MEDLINE    
Many patients have chronic, debilitating symptoms of voiding dysfunction that are refractory to conventional medical or surgical therapies. This multicenter, prospective study evaluated the long-term effectiveness of sacral nerve stimulation using the implantable Medtronic InterStim therapy for urinary control in patients with otherwise intractable complaints of urinary urge incontinence, urgency-frequency, or retention. Each patient first underwent temporary, percutaneous sacral nerve test stimulation. If at least a 50% reduction in target symptoms was documented for at least 3 days, patients received a permanent Medtronic InterStim sacral nerve stimulation system that includes a surgically implanted lead and neurostimulator. Regular follow-up was conducted with outcome data. We report here on patients who have been observed from 1.5 to 3 years postimplantation. The results demonstrate that after 3 years, 59% of 41 urinary urge incontinent patients showed greater than 50% reduction in leaking episodes per day with 46% of patients being completely dry. After 2 years, 56% of the urgency-frequency patients showed greater than 50% reduction in voids per day. After 1. 5 years, 70% of 42 retention patients showed greater than 50% reduction in catheter volume per catheterization. We conclude that the Medtronic InterStim therapy for urinary control system is an effective therapy with sustained clinical benefit for patients with intractable symptoms of urinary urge incontinence, urgency-frequency, or retention.
S W Siegel; F Catanzaro; H E Dijkema; M M Elhilali; C J Fowler; J B Gajewski; M M Hassouna; R A Janknegt; U Jonas; P E van Kerrebroeck; A A Lycklama a Nijeholt; K A Oleson; R A Schmidt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Urology     Volume:  56     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-19     Completed Date:  2001-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Metropolitan Urologic Specialists, (SWS), St. Paul, Minnesota, USA.
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MeSH Terms
Electric Stimulation Therapy* / adverse effects
Electrodes, Implanted / adverse effects
Equipment Failure
Follow-Up Studies
Foreign Bodies / etiology
Foreign-Body Migration / etiology
Lumbosacral Plexus
Middle Aged
Patient Satisfaction
Prospective Studies
Prostheses and Implants / adverse effects
Treatment Outcome
Urinary Incontinence / therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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