Document Detail

Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis.
MedLine Citation:
PMID:  20938644     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION AND HYPOTHESIS: While the short-term efficacy of intravesical hyaluronan for bladder pain syndrome/interstitial cystitis (BPS/IC) has been demonstrated, no data exist on the long-term outcome of this therapy.
METHODS: Seventy BPS/IC patients treated with intravesical hyaluronan therapy from 2001 to 2003 were asked to rate their present status of bladder symptoms on a visual analog scale.
RESULTS: Forty-eight of 70 patients responded after a mean follow-up of 4.9 years. The average initial VAS score of 8.15 had been reduced to 2.71 after therapy and further to 2.14 5 years later. Fifty percent of patients (24/48) reported complete bladder symptom remission at 5 years follow-up without any additional therapy; 41.7% (20/48) with symptom recurrence was improved with hyaluronan maintenance therapy. No improvement was reported by four patients.
CONCLUSIONS: Besides a high rate of acute symptom remission, intravesical hyaluronan also shows long-term efficacy in a considerable number of BPS/IC patients.
Paul F Engelhardt; Nike Morakis; Lukas K Daha; Britta Esterbauer; Claus R Riedl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-12
Journal Detail:
Title:  International urogynecology journal     Volume:  22     ISSN:  1433-3023     ISO Abbreviation:  Int Urogynecol J     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-06-29     Revised Date:  2011-08-18    
Medline Journal Info:
Nlm Unique ID:  101567041     Medline TA:  Int Urogynecol J     Country:  England    
Other Details:
Languages:  eng     Pagination:  401-5     Citation Subset:  IM    
Department of Urology, Landesklinikum Thermenregion Baden, Wimmergasse 19, 2500 Baden, Austria.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage*
Administration, Intravesical
Aged, 80 and over
Cystitis, Interstitial / drug therapy*
Hyaluronic Acid / administration & dosage*
Middle Aged
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Adjuvants, Immunologic; 9004-61-9/Hyaluronic Acid

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