| Long-term results of interferon alpha monotherapy in patients with HBeAg-negative chronic hepatitis B. | |
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MedLine Citation:
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PMID: 17237999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to evaluate the long-term results of interferon-alpha (IFN-alpha) therapy in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. Eighty HBeAg-negative naive patients (62 men; mean age, 39.9 years) who received IFN-alpha for 6 months were studied. Alanine aminotransferase normalization with undetectable HBV-DNA by molecular hybridization was accepted as response. All patients but 1 were precirrhotic stage. At the end of treatment, 44 (55%) patients responded, and they were followed for a mean of 59.5 months (range, 18-132). Twenty-seven patients (61.4%) showed recurrence (63% in first year). Responses at 6 months and at the end of the follow-up period 42.5% and 30% (including 7 patients without end treatment response), respectively. Recurrence of HBV replication was not detected after the 2-years follow-up period. Histologic improvement was observed in 83.3% patients with end-of-follow-up response. HBsAg became negative in 4 patients (5%). On multivariate analysis, younger age (P = .04) and lower GGT level (P = .037) were independent factors for prediction of end-of-follow-up response. Nearly half of the patients with HBeAg-negative chronic hepatitis B responds to IFN-alpha at the end of therapy. Despite the high recurrence rates, response continues in about one third of patients after a mean of 59.5 months. |
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Authors:
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Sabahattin Kaymakoglu; Ahmet Danalioglu; Kadir Demir; Cetin Karaca; Filiz Akyuz; Derya Onel; Selim Badur; Ugur Cevikbas; Fatih Besisik; Yilmaz Cakaloglu; Atilla Okten |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 52 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-04-10 Completed Date: 2007-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 727-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Capa 34390, Istanbul, Turkey. kaymakoglus@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antiviral Agents / therapeutic use* DNA, Viral / analysis Female Hepatitis B e Antigens* Hepatitis B virus / immunology Hepatitis B, Chronic / drug therapy*, immunology Humans Interferon Alfa-2a / therapeutic use Interferon Alfa-2b / therapeutic use Interferon-alpha / therapeutic use* Male Recurrence Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/DNA, Viral; 0/Hepatitis B e Antigens; 0/Interferon-alpha; 76543-88-9/Interferon Alfa-2a; 99210-65-8/Interferon Alfa-2b |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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