Document Detail


Long-term results of growth hormone therapy in Turner syndrome.
MedLine Citation:
PMID:  11572325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Short stature is one of the main features of Turner syndrome. Today, most patients are treated with growth hormone (GH) to improve adult height. We have reviewed the literature reporting adult height in patients with Turner syndrome treated with GH alone or in combination with oxandrolone. The reported adult heights as well as the height gain over projected or predicted height are still preliminary and vary considerably among studies. There is some evidence that the age of onset of therapy, dose of GH, duration of GH therapy, target height, time of estrogen substitution, or concurrent treatment with oxandrolone affect adult height. The reported height gains over projected height range from -0.20 to +16.0 cm (median: 5.1 cm) in patients treated with GH and from +0.68 cm to +10.3 (median: 6.40 cm) in patients treated with GH and oxandrolone. Thus, the presently available data are extremely varied and need further detailed analysis after all ongoing clinical trials have published the final results of all patients included in the study.
Authors:
J H Bramswig
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrine     Volume:  15     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-09-26     Completed Date:  2002-02-13     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-13     Citation Subset:  IM    
Affiliation:
University Children's Hospital, Department of Pediatrics, M?nster, Germany. bramswi@uni-muenster.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Body Height
Child
Estrogens / administration & dosage
Female
Human Growth Hormone / administration & dosage,  therapeutic use*
Humans
Oxandrolone / administration & dosage,  therapeutic use
Turner Syndrome / drug therapy*
Chemical
Reg. No./Substance:
0/Estrogens; 12629-01-5/Human Growth Hormone; 53-39-4/Oxandrolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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