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LONG-TERM RESPONSE TO ETANERCEPT MONOTHERAPY IN MODERATE TO SEVERE PSORIASIS. ASSESSMENT IN DAILY PRACTISE BY THE MAINTENANCE OF LOW VALUES OF PASI AND BSA.
MedLine Citation:
PMID:  23210771     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Introduction: Efficacy and safety of etanercept have been proved in numerous clinical trials; however efficacy is determined by means of PASI 75 and few studies consider the maintenance of long-term response. The aim of this study is to provide data on long-term response to etanercept monotherapy in daily practice and to propose a method to assess the efficacy based on the maintenance of low PASI and BSA. Methods: Patients with moderate-severe psoriasis treated with etanercept 50 mg weekly, achieving at least PASI 50 at 12 weeks, were included. Response was expressed as the percentage of patients maintaining PASI and BSA ≤5 and ≤3. Results: We included 76 patients (73.7% male and 26.3% female). PASI remained ≤5 in 71.1%, 61.3%, 54.4%, 38.3%, 8.6% and 5.9% of patients and ≤3 in 51.3%, 46.8%, 42.1%, 34%, 8.6% and 5.9% at 3, 12, 18, 24, 36 and 42 months. Conclusions: The maximum response is achieved between 6 and 9 months and remains stable in about 50% of cases until 18-24 months. Response maintains beyond 42 months in 6%. Maintenance of low PASI and BSA may be a most useful measure than the initial PASI reduction, which not always means enough improvement for the patient.
Authors:
Fernández-Torres Rosa; Paradelo Sabela; Fonseca Eduardo
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Dermatology. University Hospital of La Coruña , Spain.
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