| LONG-TERM RESPONSE TO ETANERCEPT MONOTHERAPY IN MODERATE TO SEVERE PSORIASIS. ASSESSMENT IN DAILY PRACTISE BY THE MAINTENANCE OF LOW VALUES OF PASI AND BSA. | |
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MedLine Citation:
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PMID: 23210771 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Introduction: Efficacy and safety of etanercept have been proved in numerous clinical trials; however efficacy is determined by means of PASI 75 and few studies consider the maintenance of long-term response. The aim of this study is to provide data on long-term response to etanercept monotherapy in daily practice and to propose a method to assess the efficacy based on the maintenance of low PASI and BSA. Methods: Patients with moderate-severe psoriasis treated with etanercept 50 mg weekly, achieving at least PASI 50 at 12 weeks, were included. Response was expressed as the percentage of patients maintaining PASI and BSA ≤5 and ≤3. Results: We included 76 patients (73.7% male and 26.3% female). PASI remained ≤5 in 71.1%, 61.3%, 54.4%, 38.3%, 8.6% and 5.9% of patients and ≤3 in 51.3%, 46.8%, 42.1%, 34%, 8.6% and 5.9% at 3, 12, 18, 24, 36 and 42 months. Conclusions: The maximum response is achieved between 6 and 9 months and remains stable in about 50% of cases until 18-24 months. Response maintains beyond 42 months in 6%. Maintenance of low PASI and BSA may be a most useful measure than the initial PASI reduction, which not always means enough improvement for the patient. |
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Authors:
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Fernández-Torres Rosa; Paradelo Sabela; Fonseca Eduardo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-5 |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: - ISSN: 1471-1753 ISO Abbreviation: J Dermatolog Treat Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatology. University Hospital of La Coruña , Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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