Document Detail


Long-term remission from gout associated with fenofibrate therapy.
MedLine Citation:
PMID:  12605325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Short-term studies with fenofibrate, an established treatment for hyperlipidaemia, have shown that its unique side effect of urate lowering is mediated through enhanced renal urate clearance. The long-term effects of fenofibrate on hyperuricaemia and gout have not previously been reported. We report two patients with hyperlipidaemia in association with hyperuricaemia in whom long-term fenofibrate therapy was associated with a sustained reduction in serum urate and lipid levels, together with remission from recurrent attacks of acute gout. The mechanisms involved in these effects and the potential role for fenofibrate in the management of gout are discussed.
Authors:
A L Hepburn; S A Kaye; M D Feher
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  22     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Affiliation:
Rheumatology Section, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. a.hepburn@ic.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Antilipemic Agents / therapeutic use*
Gout / complications,  drug therapy*
Humans
Hyperlipidemias / blood,  complications,  drug therapy
Hyperuricemia / blood,  complications,  drug therapy
Lipids / blood
Male
Middle Aged
Procetofen / therapeutic use*
Remission Induction
Time Factors
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Lipids; 49562-28-9/Procetofen; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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