| Long-term reduction of microalbuminuria after 3 years of angiotensin-converting enzyme inhibition by perindopril in hypertensive insulin-treated diabetic patients. | |
| | |
MedLine Citation:
|
PMID: 1580274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the long-term effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril, administered for 36 months on glycemic control, creatinine clearance, and albuminuria in hypertensive insulin-treated diabetics. After 1 month treatment with placebo, 39 patients entered the study and received 4-8 mg perindopril/day. Within the first 3 months, diastolic blood pressure was normalized in 80% of the patients. From these, 23 were followed during a total of 3 years on perindopril therapy, and divided in three groups according to their initial urinary albumin excretion rate (AER): 11 had normal AER (less than 15 mg/24 hours), eight had microalbuminuria (AER 15-150 mg/24 hour), and four had AER greater than 150 mg/24 hours and had overt proteinuria. Long-term (3 years) diastolic blood pressure normalization (less than or equal to 90 mm Hg) was achieved throughout the study. Concomitant with blood pressure reduction, a long-term decrease in AER was observed in normo- and microalbuminuric patients. Macroproteinuria was unaffected by perindopril. Glycemic control and creatinine clearance remained stable during the whole study period. No major side effects were observed. We conclude that perindopril safely produces a long-term normalization of elevated blood pressure in hypertensive insulin-treated diabetics without affecting glycemic control. Blood pressure normalization is associated with long-term AER reduction in normo- and microalbuminuric patients. |
| | |
Authors:
|
M P Hermans; S M Brichard; I Colin; P Borgies; J M Ketelslegers; A E Lambert |
Related Documents
:
|
6998684 - Comparison of the acute and chronic hemodynamic effects of captopril and guanethidine i... 3534854 - Influence of captopril on intracellular ions--a possible mode of action. 9048344 - Angiotensin-converting enzyme inhibition in the prevention and treatment of chronic ren... 8385284 - Renal responses to nifedipine and captopril in hypertensive insulin-dependent diabetic ... 8477024 - Potential risks of high-dose epinephrine for resuscitation from ventricular fibrillatio... 8262724 - Effect of calculus and irrigator tip design on depth of subgingival irrigation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of medicine Volume: 92 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-06-05 Completed Date: 1992-06-05 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 102S-107S Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, Louvain University School of Medicine, Brussels, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Albuminuria
/
complications,
drug therapy* Analysis of Variance Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Blood Glucose / analysis Creatinine / metabolism Diabetes Complications* Diabetes Mellitus / drug therapy Diabetic Nephropathies / complications, drug therapy* Female Humans Hypertension / complications, drug therapy* Indoles / therapeutic use* Insulin / therapeutic use Male Middle Aged Perindopril |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Blood Glucose; 0/Indoles; 11061-68-0/Insulin; 60-27-5/Creatinine; 82834-16-0/Perindopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnosis and interventions in lower respiratory tract infections.
Next Document: Effect of the renin-angiotensin system in the vascular disease of type II diabetes mellitus.