| Long term recombinant interferon alpha treatment in MS with special emphasis to side effects. | |
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MedLine Citation:
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PMID: 9345419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty relapsing-remitting (RR) clinically definite MS patients were treated with 9 MIU intramuscular recombinant interferon alpha-2a (rIFNA) (Roferon-A, Roche) (n = 12) or placebo (n = 8) every other day for 6 months and followed up for a further 6 months after stopping treatment. Numbers of active lesions at MRI and of patients with clinical-MRI signs of disease activity and lymphocyte interferon gamma production, which were decreased during treatment, returned to values similar to baseline and placebos after stopping treatment. rIFNA chronic therapy seems therefore needed in order to maintain drug efficacy. Side effect profile was monitored, too, for over 1 year in the same 20 patients plus 25 additional RR MS patients. Besides the typical side effects of type I interferon therapy (fever, fatigue, depression, lymphopenia, hepatic enzyme elevation), occurrence of serum autoAbs was noted in 30% patients (in 60% antinuclear and in 80% antithyroid autoAbs). In two patients rIFNA treatment was stopped, in one case for antithyroid autoAbs and hypothyroidism, in the other for antinuclear autoAbs and a five-fold increase of ALT. A careful monitoring of serum autoAbs and of signs of thyroid or liver damage must always precede and accompany longterm type I IFN therapy. |
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Authors:
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L Durelli; M R Bongioanni; B Ferrero; D Imperiale; E Verdun; A Oggero; E Gentile; G B Bradac; M Bergui; L Bergamini; B Bergamasco |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Multiple sclerosis (Houndmills, Basingstoke, England) Volume: 1 ISSN: 1352-4585 ISO Abbreviation: Mult. Scler. Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1997-12-12 Completed Date: 1997-12-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9509185 Medline TA: Mult Scler Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 366-71 Citation Subset: IM |
Affiliation:
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Clinica delle Malattie del Sistema Nervoso, Universita di Torino, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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immunology Female Follow-Up Studies Humans Interferon Type I, Recombinant / adverse effects, therapeutic use* Magnetic Resonance Imaging Male Multiple Sclerosis / drug therapy*, immunology Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Interferon Type I, Recombinant |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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