Document Detail

Long-term ranitidine treatment for the maintenance of duodenal ulcer healing.
MedLine Citation:
PMID:  6317594     Owner:  NLM     Status:  MEDLINE    
The purpose of the present trial was to verify the efficacy and safety of long-term ranitidine treatment (150 mg at bedtime for 1 year) for the maintenance of duodenal ulcer healing in 22 patients following a successful short-term course of therapy with ranitidine at the full dose of 300 mg per day. Of the 16 patients who completed the trial - there were 6 drop-outs - 4 suffered relapses during the year of treatment (25% cumulative recurrence rate), while remission persisted in the remaining 12 patients (75%). Biochemical tests revealed no statistically significant differences in mean fasting serum pepsinogen and trypsinogen as compared to mean basal values. Mean fasting serum gastrin showed a statistically significant rise from 156 +/- 27 S.D. to 258 +/- 110 S.D. pg/ml (p less than 0.01) only at the 12th month of therapy and rapidly returned to normal (162 +/- 34 S.D.) as soon as therapy was discontinued. No side-effects of any consequence were observed.
L Lombardo; G M Babando; M De La Pierre; G Masoero; C Sategna-Guidetti; P Imarisio; A Di Napoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of tissue reactions     Volume:  5     ISSN:  0250-0868     ISO Abbreviation:  Int J Tissue React     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302116     Medline TA:  Int J Tissue React     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
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MeSH Terms
Duodenal Ulcer / drug therapy*
Middle Aged
Ranitidine / administration & dosage,  therapeutic use*
Reg. No./Substance:

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