| Long-term ranitidine treatment for the maintenance of duodenal ulcer healing. | |
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MedLine Citation:
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PMID: 6317594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present trial was to verify the efficacy and safety of long-term ranitidine treatment (150 mg at bedtime for 1 year) for the maintenance of duodenal ulcer healing in 22 patients following a successful short-term course of therapy with ranitidine at the full dose of 300 mg per day. Of the 16 patients who completed the trial - there were 6 drop-outs - 4 suffered relapses during the year of treatment (25% cumulative recurrence rate), while remission persisted in the remaining 12 patients (75%). Biochemical tests revealed no statistically significant differences in mean fasting serum pepsinogen and trypsinogen as compared to mean basal values. Mean fasting serum gastrin showed a statistically significant rise from 156 +/- 27 S.D. to 258 +/- 110 S.D. pg/ml (p less than 0.01) only at the 12th month of therapy and rapidly returned to normal (162 +/- 34 S.D.) as soon as therapy was discontinued. No side-effects of any consequence were observed. |
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Authors:
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L Lombardo; G M Babando; M De La Pierre; G Masoero; C Sategna-Guidetti; P Imarisio; A Di Napoli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of tissue reactions Volume: 5 ISSN: 0250-0868 ISO Abbreviation: Int J Tissue React Publication Date: 1983 |
Date Detail:
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Created Date: 1984-02-24 Completed Date: 1984-02-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302116 Medline TA: Int J Tissue React Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 323-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Duodenal Ulcer / drug therapy* Female Humans Male Middle Aged Ranitidine / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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