| Long-term progression at individual mean intraocular pressure levels in primary open-angle and exfoliative glaucoma. | |
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MedLine Citation:
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PMID: 18850556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe progression and non-progression rates at individual mean intraocular pressure (IOP) levels for patients with primary open-angle and exfoliative glaucoma. METHODS: A meta-analysis of five previously published retrospective studies describing progression and non-progression rates at individual intraocular pressure levels over 5 or more years of follow-up. All patients had primary open-angle (four studies) or exfoliative glaucoma (one study). RESULTS: This meta-analysis included 822 patients of whom 655 (80%) had primary openangle glaucoma and 167 (20%) had exfoliative glaucoma. In total, 220 patients progressed (27%), while 602 (73%) remained stable over 5 years. The mean IOP was 20.0 for progressed and 17.1 mmHg for stable patients (p=0.0004). The peak IOP was 29.1 for progressed and 23.6 mmHg for stable patients (p=0.0014). At an IOP level >18 mmHg, 49% of patients remained stable; at 18 mmHg, 78%; between 13 and 17 mmHg, 82%; and <13 mmHg, 96%. Additional factors associated with progression were older age (p=0.0004) and exfoliative glaucoma (p=0.0001). However, multivariant regression analysis identified only mean IOP as a risk factor for progression (p=0.039). CONCLUSIONS: This study suggests that maintaining an IOP well within the normal range over 5 years in patients with primary open-angle or exfoliative glaucoma helps to prevent glaucomatousprogression. |
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Authors:
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W C Stewart; A E Kolker; E D Sharpe; D G Day; A G P Konstas; G Hollo; Y S Astakhov; M A Teus; J A Stewart |
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Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: European journal of ophthalmology Volume: 18 ISSN: 1120-6721 ISO Abbreviation: Eur J Ophthalmol Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-10-13 Completed Date: 2008-10-23 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9110772 Medline TA: Eur J Ophthalmol Country: Italy |
Other Details:
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Languages: eng Pagination: 765-70 Citation Subset: IM |
Affiliation:
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PRN Pharmaceutical Research Network, LLC, Dallas, TX, USA. info@prnorb.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Disease Progression Exfoliation Syndrome / physiopathology* Female Follow-Up Studies Glaucoma, Open-Angle / physiopathology* Humans Intraocular Pressure / physiology* Male Retrospective Studies Risk Factors Tonometry, Ocular |
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