Document Detail


Long-term prognostic value of left ventricular dyssynchrony assessment by phase analysis from myocardial perfusion imaging.
MedLine Citation:
PMID:  20962345     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective To assess the value of left ventricular (LV) dyssynchrony, using phase analysis of nuclear single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as independent predictor of cardiac events. Methods Phase analysis using Emory Cardiac Toolbox was applied on gated rest MPI scans to assess LV dyssynchrony in a total of 202 patients. Follow-up was obtained in 197 patients (97.5%). Major adverse cardiac events (MACE) (cardiac death and hospitalisation for any cardiac reasons, including worsening of heart failure, non-fatal myocardial infarction, unstable angina and coronary revascularisation) were determined using the Kaplan-Meier method. Cox proportional hazard regression was used to identify independent predictors of cardiac events. Results At a median follow-up of 3.2±1.2&emsp14;years, 41 patients had at least one event, including 5 cardiac deaths. LV dyssynchrony (n=35) was associated with a significantly higher incidence of MACE (p<0.001) and proved to be an independent predictor of cardiac events. Conclusion LV dyssynchrony assessed by phase analysis of gated SPECT-MPI is a strong predictor of MACE independent of other known predictors such as perfusion defects or decreased LV ejection fraction.
Authors:
Aju P Pazhenkottil; Ronny R Buechel; Lars Husmann; René N Nkoulou; Mathias Wolfrum; Jelena-Rima Ghadri; Janine Kummer; Bernhard A Herzog; Philipp A Kaufmann
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Publication Detail:
Type:  Journal Article     Date:  2010-10-20
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  AIM; IM    
Affiliation:
Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland; pak@usz.ch.
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