| Long-term prognostic value of left ventricular dyssynchrony assessment by phase analysis from myocardial perfusion imaging. | |
| | |
MedLine Citation:
|
PMID: 20962345 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Objective To assess the value of left ventricular (LV) dyssynchrony, using phase analysis of nuclear single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as independent predictor of cardiac events. Methods Phase analysis using Emory Cardiac Toolbox was applied on gated rest MPI scans to assess LV dyssynchrony in a total of 202 patients. Follow-up was obtained in 197 patients (97.5%). Major adverse cardiac events (MACE) (cardiac death and hospitalisation for any cardiac reasons, including worsening of heart failure, non-fatal myocardial infarction, unstable angina and coronary revascularisation) were determined using the Kaplan-Meier method. Cox proportional hazard regression was used to identify independent predictors of cardiac events. Results At a median follow-up of 3.2±1.2 years, 41 patients had at least one event, including 5 cardiac deaths. LV dyssynchrony (n=35) was associated with a significantly higher incidence of MACE (p<0.001) and proved to be an independent predictor of cardiac events. Conclusion LV dyssynchrony assessed by phase analysis of gated SPECT-MPI is a strong predictor of MACE independent of other known predictors such as perfusion defects or decreased LV ejection fraction. |
| | |
Authors:
|
Aju P Pazhenkottil; Ronny R Buechel; Lars Husmann; René N Nkoulou; Mathias Wolfrum; Jelena-Rima Ghadri; Janine Kummer; Bernhard A Herzog; Philipp A Kaufmann |
Related Documents
:
|
12628715 - Assessment of clinical features in transient left ventricular apical ballooning. 12766495 - Evidence that stunning can be cumulative in man. 3704595 - Echocardiographic assessment of left ventricular function in left ventricular volume lo... 18308025 - Prognostic value of the shock index along with transthoracic echocardiography in risk s... 17620685 - A case of hemolysis after percutaneous ventricular septal defect closure with a device. 1694915 - Effects of increased heart work on release of norepinephrine and ventricular arrhythmia... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-20 |
Journal Detail:
|
Title: Heart (British Cardiac Society) Volume: 97 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
|
Languages: eng Pagination: 33-7 Citation Subset: AIM; IM |
Affiliation:
|
Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, CH-8091 Zurich, Switzerland; pak@usz.ch. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospecti...
Next Document: An unusual connection of the right and left inferior pulmonary veins in the left atrium via a common...