Document Detail

Long-term prognostic value of exercise testing in men and women from the Coronary Artery Surgery Study (CASS) registry.
MedLine Citation:
PMID:  7732991     Owner:  NLM     Status:  MEDLINE    
Many prior studies involving a predominantly male population have demonstrated the importance of exercise test results in determining the outcome of patients with coronary artery disease. The prognostic significance of exercise testing in women is unknown. In our study, a total of 3,086 men and 747 women underwent maximal treadmill exercise testing, coronary angiography, and were prospectively followed for up to 16 years. They were divided into 3 groups (high, intermediate, and low risk) on the basis of exercise testing. Sixteen-year survival based on exercise test groups ranged from 38% to 61% in men and from 44% to 79% in women (p < 0.001). Among men, 12-year survival was enhanced by coronary artery bypass surgery versus medical therapy in the high-risk subgroup (69% vs 55%, respectively, p = 0.0025), but the 2 therapies were similar in the intermediate- and low-risk subgroups. Among women, neither medical nor surgical therapy resulted in improved 12-year survival rates in any of the 3 subgroups. These results suggest that exercise testing is helpful in assessing long-term survival in men and women. However, only exercise testing in men could identify a high-risk subset whose survival was enhanced by coronary artery bypass graft surgery.
D A Weiner; T J Ryan; L Parsons; L D Fisher; B R Chaitman; L T Sheffield; F E Tristani
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  75     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-01     Completed Date:  1995-06-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-70     Citation Subset:  AIM; IM    
Evans Medical Department of Clinical Research, Boston University Medical Center Hospital, Massachusetts 02118-2393, USA.
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MeSH Terms
Coronary Artery Bypass*
Coronary Disease / diagnosis,  drug therapy,  mortality*,  surgery
Exercise Test*
Middle Aged
Proportional Hazards Models
Prospective Studies
Risk Factors
Sex Factors
Survival Analysis
Survival Rate
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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