Document Detail

Long-term prognostic value of early poststress (99m)Tc-tetrofosmin lung uptake during exercise (SPECT) myocardial perfusion imaging.
MedLine Citation:
PMID:  20016896     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to determine the long-term prognostic value of early poststress lung/heart ratio (LHR) of (99m)Tc-tetrofosmin radioactivity. METHODS: We studied 276 patients (aged 62.2 + or - 8.9 years, 168 men) with stress/rest (99m)Tc-tetrofosmin myocardial gated-SPECT and coronary angiography. To evaluate myocardial ischaemia, we calculated the summed stress score, summed rest score and summed difference score indices. For the eLHR calculation, an anterior image was acquired, 4-6 min after radiotracer injection at stress (eLHR was defined as mean counts per pixel in the lung region of interest divided by the mean counts per pixel in the myocardial region of interest). Cardiovascular death and nonfatal myocardial infarction were considered as hard cardiac events, and late revascularization procedures as soft cardiac events. The Cox proportional hazards model in a stepwise method was used to determine the independent predictors for hard and soft cardiac events. RESULTS: During the follow-up period hard cardiac events occurred in 28 patients (10.1%) and soft cardiac events in 32 patients (11.6%). Implying multiple Cox regression analysis, eLHR was found to be a significant independent predictor for both soft and hard cardiac events. The hazard ratio (for a 0.1 unit increase) was 4.41 (95% CI 1.52-12.73, p=0.006) for soft cardiac events and 4.22 (95% CI 2.07-8.62, p<0.001) for hard cardiac events. The other significant prognostic factors were use of beta-blockers, the summed stress score and the use of nitrates for soft events, and exercise duration and the summed stress score for hard cardiac events. CONCLUSION: Early poststress (99m)Tc-tetrofosmin LHR has an independent and powerful value in predicting hard and soft cardiac events.
Panagiotis Georgoulias; Ioannis Tsougos; Varvara Valotassiou; Chara Tzavara; Petros Xaplanteris; Nikolaos Demakopoulos
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Publication Detail:
Type:  Journal Article     Date:  2009-12-17
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  37     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  789-98     Citation Subset:  IM    
Department of Nuclear Medicine, University Hospital of Larissa, Mezourlo, Larissa, 41110, Greece.
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MeSH Terms
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography*
Cardiovascular Diseases / mortality*
Coronary Angiography
Coronary Disease / radiography,  radionuclide imaging
Exercise Test*
Heart Catheterization
Kaplan-Meiers Estimate
Lung / radionuclide imaging*
Middle Aged
Myocardial Infarction / epidemiology*,  therapy
Myocardial Perfusion Imaging*
Myocardial Revascularization / statistics & numerical data
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Proportional Hazards Models
Radiopharmaceuticals / diagnostic use*
Single-Blind Method
Smoking / epidemiology
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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