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Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.
MedLine Citation:
PMID:  21482708     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
For establishing the true impact of different response categories in multiple myeloma patients treated with autologous stem cell transplantation we evaluated, after a median follow-up of 153 months, 344 MM patients transplanted between 1989 and 1998. OS at 12 years were 35% in Complete Response (CR) patients, 22% in Near Complete Response (nCR), 16% in Very Good Partial Response (VGPR), and 16% in Partial Response (PR) groups. Significant differences in OS and PFS were found between CR and nCR groups (P=.01 and .002, respectively), between CR and VGPR (P= .0001 and .003) or between CR and PR (P= .003 and <10(-5)); no differences were observed between the nCR and VGPR groups (P= .2 and .9) or between these groups and the PR group (P= .1 and .8). A landmark study found a plateau phase in OS after 11 years; 35% patients in the CR group and 11% in the nCR+VGPR+PR group are alive at 17 years; two cases had relapsed in the nCR+VGPR+PR group. Conclusion, in MM achieving CR after autologous stem cell transplantation is a central prognostic factor. The relapse rate is very low in patients with >11 years of follow-up, possibly signifying a cure for patients in CR.
Authors:
Joaquin Martinez-Lopez; Joan Blade; María-Victoria Mateos; Carlos Grande; Adrián Alegre; José García-Laraña; Anna Sureda; Javier de la Rubia; Eulogio Conde; Rafael Martinez; Felipe de Arriba; Maria C Viguria; Joan Besalduch; Rafael Cabrera; José D Gonzalez-San Miguel; José Luis Guzman-Zamudio; Maria Carmen Gomez Del Castillo; José Maria Moraleda; Juan C García-Ruiz; Jesús San Miguel; Juan José Lahuerta
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-11
Journal Detail:
Title:  Blood     Volume:  -     ISSN:  1528-0020     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Hospital Universitario 12 de Octubre, Madrid, Spain;
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