Document Detail

Long-term prognosis of patients with variant angina.
MedLine Citation:
PMID:  3665004     Owner:  NLM     Status:  MEDLINE    
The long-term prognosis of variant angina and the factors influencing it were assessed in 217 consecutive patients hospitalized in our coronary care unit and followed for a mean of 65 months (range 2 to 123). Cardiac death occurred in 30 patients and an additional 54 experienced a nonfatal myocardial infarction. Survival at 1 and 5 years was 95% and 89%, respectively; survival without infarction was 83% and 69%. Coronary disease and the degree of disease activity were strong predictors of survival by Cox analysis. Survival at 1 year was 99%, and that at 5 years was 95% and 94%, respectively, for patients with one-vessel disease (n = 81) and for those without stenoses of 70% or greater (n = 87). Survival at 1 and 5 years was only 87% and 77% for those with multivessel disease (n = 40). The Cox analysis selected left ventricular function, initial treatment, extent score, duration of angina at rest, and disease activity as multivariate predictors of survival without infarction. Coronary disease was a strong predictor (p less than .0001) of survival without infarction by univariate analysis. Treatment with nifedipine, diltiazem, or verapamil improved survival without infarction compared with other medical treatment (p = .002). Myocardial infarction occurred most commonly soon after diagnosis in patients with a short history of angina at rest. Late coronary events were almost never preceded by resting angina.
A Walling; D D Waters; D D Miller; D Roy; G B Pelletier; P Théroux
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  76     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Nov 
Date Detail:
Created Date:  1987-12-10     Completed Date:  1987-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  990-7     Citation Subset:  AIM; IM    
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
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MeSH Terms
Angina Pectoris, Variant / diagnosis,  mortality*,  therapy
Cause of Death
Follow-Up Studies
Heart Ventricles / physiopathology
Middle Aged
Myocardial Infarction / mortality
Prospective Studies

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