Document Detail

Long-term prognosis of mitral-valve prolapse.
MedLine Citation:
PMID:  865549     Owner:  NLM     Status:  MEDLINE    
We examined the natural history of mitral-valve prolapse in 53 patients who had had a midsystolic click or late systolic murmur (or both) documented phonocardiographically a mean of 13.7 years earlier. Thirty-eight patients were alive without serious complications, and seven had died of unrelated causes. In two patients prolapse was implicated in the cause of death. Other complications were ventricular fibrillation in one patient and bacterial endocarditis in three. Progressive mitral regurgitation developed in five patients, requiring valve replacement in two. These complications occurred in a total of eight patients (15 per cent), and were significantly (P = 0.15) associated with a late systolic murmur rather than an isolated midsystolic click. Thus it appears that the diagnosis of mitral-valve prolapse should not be regarded as ominous; however, patients in whom this diagnosis is associated with a late systolic murmur should be followed carefully.
P Mills; J Rose; J Hollingsworth; I Amara; E Craige
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  297     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  AIM; IM    
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MeSH Terms
Endocarditis, Bacterial / complications
Follow-Up Studies
Heart Sounds
Middle Aged
Mitral Valve Insufficiency / complications,  diagnosis,  mortality*
Time Factors
Ventricular Fibrillation / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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