Document Detail

Long-term prognosis for infants after massive fetomaternal hemorrhage.
MedLine Citation:
PMID:  17666598     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the fetal, neonatal, and long-term prognosis of massive fetomaternal hemorrhage (20 mL or more). METHODS: This series includes all patients with Kleihauer test values of 40 per 10,000 or higher over an 8-year period at two university hospitals. We examined obstetric, neonatal, and subsequent outcome data for the children. RESULTS: During the study period, 48 patients had massive fetomaternal hemorrhage (crude incidence 1.1 per 1,000; corrected incidence for Rh-negative women 4.6 per 1,000). Six fetal deaths were observed, representing 1.6% of all fetal deaths during the period. Nine newborns (18.7%) were transferred to neonatal intensive care unit (NICU) and five (10.4%) had transfusions. Fetomaternal hemorrhages of 20 mL/kg or more significantly increased the risk of fetal death, induced preterm delivery, transfer to NICU, and neonatal anemia requiring transfusion. Long-term follow-up was not associated with neurological sequelae (0%, 95% confidence interval 0.0-11.6%). CONCLUSION: When the transfused volume equals or exceeds 20 mL/kg, massive fetomaternal hemorrhage may lead to severe prenatal or neonatal complications. LEVEL OF EVIDENCE: III.
Chrystèle Rubod; Philippe Deruelle; Francoise Le Goueff; Virginie Tunez; Martine Fournier; Damien Subtil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  110     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-08-30     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  AIM; IM    
Hôpital Jeanne de Flandre, Université Lille II, 1 rue Eugène Avinée, 59037 Lille Cedex, France.
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MeSH Terms
Anemia, Neonatal / blood,  diagnosis
Blood Transfusion
Child, Preschool
Fetal Death / etiology*
Fetomaternal Transfusion / complications*
Follow-Up Studies
Infant, Newborn
Retrospective Studies

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