Document Detail

Long-term prognosis after coronary bypass surgery depends on interleukin 6 polymorphism and past acute infections.
MedLine Citation:
PMID:  17023074     Owner:  NLM     Status:  MEDLINE    
We were seeking for a mutual link between the -174G>C IL6 promoter polymorphism, history of the past acute respiratory infections and the long-term post-coronary artery bypass grafting (CABG) major adverse cardiovascular events (MACE) incidence. Two hundred thirty seven post-CABG patients have been followed up for a median period of 36 months. We found that past acute infections, influenza-like illness and lack of vaccination against influenza confer a significant risk of the post-CABG MACE incidence in the -174G allele carrying patients.
Jolanta Myśliwska; Joanna Wieckiewicz; Lukasz Hak; Janusz Siebert; Jan Rogowski; Krzysztof Szyndler; Andrzej Myśliwski
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2006-10-04
Journal Detail:
Title:  International journal of cardiology     Volume:  118     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-07-23     Revised Date:  2007-08-17    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  421-2     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Cohort Studies
Coronary Artery Bypass / adverse effects,  statistics & numerical data*
Coronary Disease / genetics*,  mortality,  surgery*
Gene Expression Regulation
Influenza, Human / epidemiology
Interleukin-6 / genetics*
Middle Aged
Polymorphism, Genetic*
Postoperative Complications / epidemiology*
Respiratory Tract Infections / epidemiology
Risk Assessment
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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