Document Detail

Long-term prognosis for Guillain-Barré syndrome: evaluation of prognostic factors and clinical experience of automated double filtration plasmapheresis.
MedLine Citation:
PMID:  14699593     Owner:  NLM     Status:  MEDLINE    
Sixty patients with Guillain-Barré syndrome (GBS), aged 16-83 years, have been identified over a period of 7 years. Of 60 patients, 30 received the double filtration plasmapheresis (DFP), 4 received intravenous immunoglobulin, and the other 26 received supportive care only. Therapeutic outcomes at 1 year were determined using a modified Barthel index. At a follow-up of 1 year or longer, 31 patients (52%) had recovered, 24 (40%) had residua, and 5 (8%) had died. According to the statistical analysis, disability at the nadir and electrophysiological signs significantly influenced the long-term outcomes. Complications associated with DFP procedures included physiologic change, technique-related complications, and vascular access-related complications. None of our patients had fatal complications related to DFP treatment. Contrary to the established belief that the disease has a favorable outcome, several hospital-treated patients may still die or present residua even several months after the onset of symptoms. Because disability at the nadir influences the outcomes, early diagnosis and choice of appropriate treatment, which might include DFP, to prevent further neurological deficits, are essential to maximize the potential for survival.
Ben-Chung Cheng; Wen-Neng Chang; Jin-Bor Chen; Esther Chung-Yin Chee; Chi-Ren Huang; Cheng-Hsien Lu; Chin-Jung Chang; Pi-Lien Hung; Yao-Cheng Chuang; Chien-Te Lee; Ping-Yu Lee; Kuo-Wei Wang; Hsueh-Wen Chang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  18     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-30     Completed Date:  2004-04-14     Revised Date:  2005-07-26    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Division of Nephrology, Department of Medicine, Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung, Taiwan.
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MeSH Terms
Aged, 80 and over
Guillain-Barre Syndrome / etiology*,  physiopathology,  therapy*
Immunoglobulins, Intravenous / therapeutic use
Middle Aged
Plasmapheresis / adverse effects,  methods*
Retrospective Studies
Reg. No./Substance:
0/Immunoglobulins, Intravenous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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