Document Detail

Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats.
MedLine Citation:
PMID:  15352134     Owner:  NLM     Status:  MEDLINE    
In order to determine the influence of long-term prenatal hypoxia on the maturation of the brain catecholaminergic structures involved in motor and cognitive functions, pregnant rats were subjected to hypoxia (10% O2) from the 5th to 20th day of gestation. The in vivo activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, was assessed, by accumulation of L-DOPA after i.p. administration of NSD-1015, in the motor cortex areas, the hippocampus, and the striatum at birth and at the 3rd, 7th, 14th, 21st, and 68th postnatal days. The motor reactivity to novelty and the circadian motor activity were measured at the 21st and 68th postnatal days. Exposure to prenatal hypoxia strongly altered the developmental pattern of in vivo TH activity in restricted noradrenergic terminals of the brain. In the 21-day-old prenatal hypoxic rats, the TH activity was reduced by 80% in the motor cortex areas and by 43% in the hippocampus, compared to control rats, while no differences could be detected in the striatum. Compared to control rats, the prenatal hypoxic pups exhibited a higher motor reactivity to novelty and a nocturnal motor hypoactivity at the 21st postnatal day. The neurochemical and behavioral alterations were no longer observed at the 68th postnatal day. The altered in vivo TH activity in the young rats might be part of the neural mechanisms contributing to the motor behavioral impairments induced by prenatal hypoxia. Long-term prenatal hypoxia could be linked to the development of psychopathologies that can be detected in infancy.
David Perrin; Julie Mamet; Hélène Scarna; Jean Christophe Roux; Anne Bérod; Yvette Dalmaz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  54     ISSN:  0887-4476     ISO Abbreviation:  Synapse     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-09-07     Completed Date:  2004-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-101     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Laboratoire de Physiologie Intégrative, Cellulaire et Moléculaire UMR CNRS 5123, Université Claude Bernard, Lyon, France.
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MeSH Terms
Age Factors
Analysis of Variance
Anoxia* / metabolism,  physiopathology
Behavior, Animal
Body Weight
Brain / anatomy & histology,  drug effects,  growth & development,  metabolism*
Brain Chemistry / drug effects
Catecholamines / metabolism*
Enzyme Inhibitors / pharmacology
Exploratory Behavior
Hydrazines / pharmacology
Levodopa / metabolism
Motor Activity / physiology*
Organ Size
Prenatal Exposure Delayed Effects*
Time Factors
Tyrosine 3-Monooxygenase / metabolism
Reg. No./Substance:
0/Catecholamines; 0/Enzyme Inhibitors; 0/Hydrazines; 0/Levodopa; 637-33-2/3-hydroxybenzylhydrazine; EC 3-Monooxygenase

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