Document Detail


Long-term potentiation of glutamatergic synaptic transmission induced by activation of presynaptic P2Y receptors in the rat medial habenula nucleus.
MedLine Citation:
PMID:  12603274     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel form of long-term potentiation of glutamatergic synaptic transmission is described in the rat medial habenula nucleus. It occurs when uridine 5'-triphosphate is bath applied at low micromolar concentrations and is prevented by Reactive Blue 2, suggesting that it is mediated by P2Y4 receptors. Uridine 5'-diphosphate can also cause such a Reactive Blue 2-sensitive potentiation, but at higher concentrations (200 microm), suggesting that this might also be an effect on the relatively uridine 5'-diphosphate-insensitive P2Y4 receptor. The potentiation is due to an increase in presynaptic release probability. It requires neither depolarization nor calcium influx postsynaptically and is thus probably non-Hebbian. When potentiation due to low concentrations of uridine 5'-triphosphate is inhibited in the presence of Reactive Blue 2, uridine 5'-triphosphate causes instead a significant inhibition of glutamate release. We suggest that this inhibition may be mediated by a Reactive Blue 2-insensitive P2Y2-like receptor. At higher concentrations of uridine 5'-triphosphate (200 micro m), the inhibitory effect dominates such that even in the absence of Reactive Blue 2 no potentiation is seen.
Authors:
Gareth D Price; Susan J Robertson; Frances A Edwards
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European journal of neuroscience     Volume:  17     ISSN:  0953-816X     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2004-04-21     Revised Date:  2010-01-14    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Affiliation:
Department of Physiology, University College London, Gower St, London WC1E 6BT, UK.
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MeSH Terms
Descriptor/Qualifier:
6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
Animals
Animals, Newborn
Dose-Response Relationship, Drug
Drug Interactions
Electric Stimulation / methods
Enzyme Inhibitors / pharmacology
Evoked Potentials / drug effects,  radiation effects
Excitatory Amino Acid Antagonists / pharmacology
Glutamic Acid / metabolism*
Habenula / cytology,  drug effects,  physiology*,  secretion
Long-Term Potentiation / physiology*,  radiation effects
Patch-Clamp Techniques / methods
Presynaptic Terminals / drug effects,  physiology*,  radiation effects
Rats
Rats, Sprague-Dawley
Receptors, Purinergic P2 / physiology*
Synaptic Transmission / drug effects,  physiology*,  radiation effects
Triazines / pharmacology
Uridine Diphosphate / pharmacology
Uridine Triphosphate / pharmacology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Excitatory Amino Acid Antagonists; 0/Receptors, Purinergic P2; 0/Triazines; 0/purinergic receptor P2Y2; 115066-14-3/6-Cyano-7-nitroquinoxaline-2,3-dione; 12236-82-7/Cibacron Blue F 3GA; 56-86-0/Glutamic Acid; 58-98-0/Uridine Diphosphate; 63-39-8/Uridine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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