Document Detail

Long term postnatal development of insulin secretion in early premature infants.
MedLine Citation:
PMID:  3522195     Owner:  NLM     Status:  MEDLINE    
The postnatal development of insulin secretion was studied in a group of premature infants (26-30 weeks gestation at birth) for periods up to 110 days after birth and in a small group of full-term infants (38-42 weeks gestation) for up to 47 days after birth. Circulating insulin levels were measured before, and at 30 min after the commencement of a glucose infusion given either parenterally or enterally depending on conceptual age and the mode of nutrition of the infant. The insulin response was assessed as the ratio of the increase in plasma insulin concentration to the increase in blood glucose concentration at 30 min. There was a small insulin response to glucose on day 1 in the premature infants and this increased slowly over the remainder of the study period regardless of the route of administration of glucose or of the mode of nutrition. The full-term infants were more responsive over the seven postnatal weeks in which they were studied. It is concluded that early premature infants can take up to eighteen weeks to develop an ability to respond fully to hyperglycaemia with insulin secretion even though full oral nutrition had been established over the last twelve weeks.
R A King; R M Smith; G W Dahlenburg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  13     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-30     Completed Date:  1986-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  285-94     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Birth Weight
Blood Glucose / metabolism
Gestational Age
Glucose / administration & dosage,  diagnostic use
Infant, Newborn
Infant, Premature*
Infusions, Intra-Arterial
Infusions, Parenteral
Insulin / blood,  secretion*
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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