| Long-term post-treatment follow-up of onychomycosis treated with terbinafine: a multicentre trial. | |
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MedLine Citation:
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PMID: 9610137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1991 and 1993, 32 cases of fingernail mycosis and 20 cases of toenail mycosis caused by dermatophytes were treated with terbinafine. For 8 weeks, 250 mg of terbinafine was given daily for fingernail infections, and for 12 weeks the same dose was given for toenail involvement; the short-term follow-up was 24 and 48 weeks respectively. A long-term follow-up was performed twice, initially at 24 and then at 48 months after the end of the treatment. For fingernail mycosis, the mycological cure rate was 100% at the end of month 24 and 91% at the end of month 48. Mycological cultures gave negative results in toenail infections in 90% after 24 months and in 86% after 48 months. After 24 months, 23 out of 26 patients (88%) with fingernail and 17 out of 20 patients (95%) with toenail mycosis were clinically cured. After 48 months, 20 out of 22 cases (91%) with fingernail and 10 out of 14 cases (71%) with toenail involvement showed a complete cure. |
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Authors:
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I Török; G Simon; A Dobozy; B Farkas; C Mészáros; L Nebenführer; E Szepes; E Tóth |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Mycoses Volume: 41 ISSN: 0933-7407 ISO Abbreviation: Mycoses Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-06-23 Completed Date: 1998-06-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8805008 Medline TA: Mycoses Country: GERMANY |
Other Details:
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Languages: eng Pagination: 63-5 Citation Subset: IM |
Affiliation:
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Department of Dermato-Venereology, Semmelweis University of Medicine, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antifungal Agents / therapeutic use* Female Follow-Up Studies Humans Male Nail Diseases / microbiology* Naphthalenes / therapeutic use* Onychomycosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Naphthalenes; 91161-71-6/terbinafine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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