| Long-term physiological and behavioral effects of exposure to a highly palatable diet during the perinatal and post-weaning periods. | |
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MedLine Citation:
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PMID: 20688090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Environmental conditions promote weight gain in children and adults, with early nutritional states and the availability of energy condensed/high-fat palatable diets appearing to facilitate the development of obesity. Little is known about the extent to which prenatal and postnatal dietary manipulations alter the response of the adult offspring to high-fat, highly palatable diets. Here we exposed rat dams to highly palatable diet (supplemental diet, SD), rich in fat and sugars, during pregnancy and lactation, and assessed the potential interactions with the effects of a similar diet offered post-weaning on a range of physiological and behavioral parameters in the adult male offspring. Post-weaning exposure to SD increased body weight, body fat, and plasma leptin levels, as well as the plasma glucose response to glucose challenge, compared to chow-fed rats. Combining perinatal SD with post-weaning exposure (SD/SD group) elevated fasting plasma glucose levels, and induced leptin resistance in the adult rats. The same treatment also resulted in sensitized locomotor response to an acute injection of amphetamine. The glucocorticoid response to stress was not affected by the dietary treatments. We conclude that exposure of mother and young to a highly palatable diet with high-fat and high sugar content during the critical perinatal period, increases the risk of developing an obesity-like condition in rats exposed to the same palatable diet post-weaning, and this effect may be accompanied by adaptations in the reward-related mesostriatal dopaminergic system. |
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Authors:
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Uri Shalev; Alana Tylor; Kristin Schuster; Claudia Frate; Stephanie Tobin; Barbara Woodside |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-03 |
Journal Detail:
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Title: Physiology & behavior Volume: 101 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 494-502 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Psychology, Center for Studies in Behavioral Neurobiology/Groupe de Recherche en Neurobiologie Comportementale, Concordia University, Montreal, Quebec, Canada. uri.shalev@concordia.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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physiology Age Factors Amphetamine / pharmacology Animal Nutritional Physiological Phenomena Animals Appetite Regulation / physiology* Association Learning / physiology* Behavior, Animal / drug effects, physiology Blood Glucose / metabolism Body Weight / physiology* Central Nervous System Stimulants / pharmacology Conditioning (Psychology) / physiology Critical Period (Psychology)* Dietary Fats Eating / physiology*, psychology Female Food Preferences / physiology*, psychology Leptin / blood Male Motivation / physiology Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Reward Taste / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Central Nervous System Stimulants; 0/Dietary Fats; 0/Leptin; 300-62-9/Amphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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