Document Detail

Long-term physical exercise and quantitatively assessed human coronary collateral circulation.
MedLine Citation:
PMID:  9669248     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This prospective, cross-sectional study sought to determine an association between the level of long-term physical activity as well as other clinical and angiographic variables and an index of collateral flow to the vascular region undergoing percutaneous transluminal coronary angioplasty (PTCA). BACKGROUND: There is limited and conflicting information about the effect of physical exercise on the coronary collateral circulation in humans, partly because previous studies lacked a quantitative means of assessing collateral channels. METHODS: In 79 patients (mean [+/-SD] age 58 +/- 10 years) with coronary artery disease undergoing PTCA (no transmural myocardial infarction), a coronary collateral flow index was determined as the ratio between the intracoronary (IC) distal flow velocity time integral during (Vi(occl)[cm]) and after (Vi(occl) [cm]) PTCA of the stenosis. Vi(occl)/Vi(occl) was measured by a 0.014-in. Doppler guide wire, from which an IC electrocardiogram (ECG) was also recorded. Patients without ECG ST-T wave changes during PTCA were considered to have sufficient collateral channels (n = 29); those with ST-T wave changes were considered to have insufficient collateral channels (n = 50). The level of long-term physical activity was determined by a structured interview (score from 1 to 4). Univariate and multivariate analyses were used to find associations between physical activity as well as 30 other clinical and angiographic variables and the collateral flow index. RESULTS: Long-term physical activity during leisure time, but not during work hours, and the severity of the stenosis undergoing PTCA were found to be independently and directly associated with sufficient versus insufficient collateral channels and with Vi(occl) Vi(occl) (leisure time physical activity [LTPA] score 3.3 +/- 0.9 vs. 2.4 +/- 1.0, p = 0.0002; percent diameter stenosis 88 +/- 12% vs. 80 +/- 14%, p = 0.001; Vi(occl)/Vi(occl) = 0.1 +/- 0.1 LTPA score, p = 0.0002 for trend). CONCLUSIONS: In patients with coronary artery disease, the level of long-term physical activity during leisure time and the severity of the stenosis undergoing PTCA are directly associated with the quantitative degree of collateral flow.
S Senti; M Fleisch; M Billinger; B Meier; C Seiler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  32     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-07-22     Completed Date:  1998-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  AIM; IM    
Section of Cardiology, University Hospital, Bern, Switzerland.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Blood Flow Velocity / physiology
Collateral Circulation / physiology
Coronary Angiography
Coronary Circulation / physiology*
Coronary Disease / physiopathology*,  therapy,  ultrasonography
Cross-Sectional Studies
Echocardiography, Doppler
Exercise / physiology*
Follow-Up Studies
Middle Aged
Physical Fitness / physiology
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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