Document Detail

Long-term pertussis-specific immune responses to a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine in pre-term infants.
MedLine Citation:
PMID:  12126904     Owner:  NLM     Status:  MEDLINE    
Immunoglobulin G (IgG) antibody titres against pertussis antigens, Bordetella pertussis-specific proliferation and cytokine production by peripheral blood mononuclear cells (PBMCs) were evaluated at the age of 5-6 years in 13 children who had been pre-term infants with a gestational age (GA) of < or = 31 weeks, 10 who had been pre-term infants with a GA of 32-37 weeks, and 15 who had been term infants with a GA of 38-42 weeks. All of the infants had been immunised with a combined diphtheria, tetanus, tricomponent acellular pertussis and hepatitis B vaccine (DTaP-HBV) at 3, 5, and 11 months of post-natal age. Our results show that the long-term immune responses induced by primary pertussis vaccination in the pre-term infants (especially those with a GA of < or = 31 weeks) were qualitatively and quantitatively lower than those observed in the term infants. In order to maintain an adequate pertussis-specific immune response, in term children a booster at 5-6 years of age may be suggested, whereas in pre-term an earlier booster should be useful.
Susanna Esposito; Giacomo Faldella; Anna Giammanco; Samantha Bosis; Ornella Friscia; Mario Clerici; Nicola Principi
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vaccine     Volume:  20     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-19     Completed Date:  2003-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  England    
Other Details:
Languages:  eng     Pagination:  2928-32     Citation Subset:  IM    
Pediatric Department I, University of Milan, Via Commenda 9, 20122 Milan, Italy.
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MeSH Terms
Age Factors
Antibodies, Bacterial / blood
Bordetella pertussis / immunology
Case-Control Studies
Child, Preschool
Cytokines / biosynthesis
Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage,  immunology*
Haemophilus Vaccines / administration & dosage,  immunology*
Hepatitis B Vaccines / administration & dosage,  immunology*
Immunity, Cellular
Immunization Schedule
Immunization, Secondary
Immunoglobulin G / blood
Infant, Newborn
Infant, Premature / immunology*
Lymphocyte Activation
Time Factors
Whooping Cough / immunology*,  prevention & control*
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Cytokines; 0/Diphtheria-Tetanus-Pertussis Vaccine; 0/Haemophilus Vaccines; 0/Hepatitis B Vaccines; 0/Immunoglobulin G; 0/diphtheria-tetanus-acellular pertussis-Hib-hepatitis B vaccine

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