Document Detail

Long-term performance of active-fixation pacing leads: a prospective study.
MedLine Citation:
PMID:  16606388     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite the increasingly widespread use of active-fixation leads, long-term clinical follow-up of pacing lead outcomes is lacking. The aim was to analyze pacing parameters over a 2-year follow-up. We performed a prospective observational study of consecutive new pacemaker implants using the 1488T St. Jude (100) and the Medtronic 5076 (100) active-fixation leads. Detailed analysis of pacing parameters was collected at implant, day 1, and 1, 3, 6, 12, 18, and 24 months. METHODS AND RESULTS: One hundred patients underwent implantation of 100 dual-chamber pacemakers. Initial pacing parameters in the ventricle were threshold 0.7 +/- 0.2 V, R wave 12.0 +/- 6.5 mV, and impedance 879 +/- 224 Omega. Threshold increased significantly from day 1 (0.7 +/- 0.2 V) to month 1 (0.9 +/- 0.6 V, P < 0.01) and remained stable over the long term. Four of the 100 patients had a threshold >2 V (mean 3.3 +/- 0.9 V) all between day 1 and month 3. For all patients, R wave remained stable, but impedance declined significantly from day 1 (879 +/- 184 Omega) to month 1 (677 +/- 122 Omega, P < 0.01). There were no ventricular lead complications. Initial pacing parameters in the atrium were threshold 0.9 +/- 0.3 V, P wave 3.3 +/- 2.4 mV, and impedance 606 +/- 144 Omega. Threshold remained stable over the long-term follow-up. One of 100 patients had a rise in threshold >2 V (2.2 V) between day 1 and month 1. No patients underwent lead repositioning. Sensing and impedance remained stable over the long term. Patient follow-up was completed in 94% (6 unrelated deaths). There was an 8% incidence of atrial fibrillation. CONCLUSION: Active-fixation leads are generally associated with stable long-term pacing parameters.
Peter M Kistler; Gary Liew; Harry G Mond
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  29     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-11     Completed Date:  2006-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  226-30     Citation Subset:  IM    
Department of Cardiology, The Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
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MeSH Terms
Australia / epidemiology
Cardiac Pacing, Artificial / statistics & numerical data*
Electrodes, Implanted*
Equipment Failure Analysis
Longitudinal Studies
Pacemaker, Artificial / statistics & numerical data*
Prospective Studies
Treatment Outcome
Ventricular Fibrillation / epidemiology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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