Document Detail


Long-term patient and graft survival in the eurotransplant senior program: a single-center experience.
MedLine Citation:
PMID:  16177629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The Eurotransplant Senior Program (ESP) was launched in 1999, targeted to increase the supply of donor kidneys to the elderly. This program requires local allocation of kidneys from cadaveric donors >>65 years to recipients >>65 years. METHODS: Of all patients >>65 years who received a kidney transplant in 1999-2002 at our center, 59 patients were transplanted through the ESP protocol (ESP group), and 44 patients received a transplant from a younger donor (EuroTransplant Kidney Allocation System, ETKAS group). Recipients were followed for up to 5.3 years using the Austrian Dialysis and Transplant Registry. Outcomes studied included all-cause mortality and allograft loss. RESULTS: Age, sex, and comorbid conditions did not differ by group. Donor age was higher (69 vs. 36 years; P < 0.001) and cold ischemia time shorter in the ESP group (10 vs. 15 hr; P < 0.001). Number of HLA mismatches was greater in the ESP group (3.8 vs. 3.0; P = 0.003). ESP patients were more likely to receive induction therapy and less likely to receive cyclosporine A. Primary nonfunction, delayed graft function, operative mortality, rate of acute rejection episodes, and length of stay did not differ by group. Although serum creatinine at discharge was higher in ESP patients (1.7 vs. 1.4 mg/dL; P < 0.001), 4-year mortality (hazard ratio [HR] = 0.68; 95% CI: 0.31-1.49) and graft loss (HR = 0.61; 95% CI: 0.29-1.28) tended to be less. CONCLUSIONS: Long-term patient and graft survival were comparable between elderly patients who received their organ via the ESP and the regular ETKAS algorithm.
Authors:
Veronika Fabrizii; Josef Kovarik; Martin Bodingbauer; Reinhard Kramar; Walter H Hörl; Wolfgang C Winkelmayer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  80     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-22     Completed Date:  2005-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  582-9     Citation Subset:  IM    
Affiliation:
Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aging*
Cadaver
Cohort Studies
Europe / epidemiology
Female
Follow-Up Studies
Graft Survival*
Humans
Immunosuppression / methods
Kidney Transplantation / mortality*
Male
Postoperative Complications / mortality
Program Evaluation
Survival Analysis
Tissue Donors / statistics & numerical data*
Tissue and Organ Procurement / statistics & numerical data
Treatment Outcome
Comments/Corrections
Comment In:
Transplantation. 2005 Sep 15;80(5):571-2   [PMID:  16177627 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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