Document Detail

Long-term pathologic consequences of acute irritant-induced asthma.
MedLine Citation:
PMID:  19895985     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Acute irritant-induced asthma (IrIa) or reactive airways dysfunction syndrome is caused by exposure to a high concentration of an agent. The long-term pathologic consequences of IrIa remain thus far unknown. OBJECTIVE: The aim of our study was to investigate the chronic airway inflammation and remodeling that occur in association with IrIa. METHODS: Ten subjects with a history of IrIa (mean interval of 10.9 years, minimum of 4 years, since the inhalational accident) underwent bronchoscopy followed by bronchoalveolar lavage and bronchial biopsies. Immunologic and morphologic data from patients with IrIa were compared with those of patients with mild to moderate asthma as well as healthy controls. RESULTS: Bronchoalveolar lavage fluid analysis showed increased eosinophil and neutrophil counts in 30% and 60% of subjects with IrIa, respectively. In the supernatant of bronchoalveolar lavage, we found a significant increase in the majority of mediators compared with healthy subjects and a significant increase in eosinophilic cationic protein, IL-8, basic fibroblast growth factor, and matrix metalloproteinase 1 compared with control patients with asthma. Evaluation of basement membrane thickness (subepithelial fibrosis) demonstrated a significant increase in patients with IrIa compared with healthy subjects and subjects with asthma. Basement membrane thickness also significantly correlated with the PC(20) value. The epithelial cell detachment showed an elevated although not significant trend compared with subjects with asthma and control subjects. Immunocytochemical analysis demonstrated increases in the number of eosinophil cationic protein and TGF-beta1-positive cells compared with healthy controls. CONCLUSION: This study provides evidence of a significant eosinophilic and neutrophilic inflammation as well as remodeling in IrIa many years after an inhalational accident.
Naoya Takeda; Karim Maghni; Sylvie Daigle; Jocelyne L'Archevêque; Lucero Castellanos; Wisam Al-Ramli; Jean-Luc Malo; Qutayba Hamid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  124     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2009-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  975-81.e1     Citation Subset:  AIM; IM    
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Acute Disease
Asthma / chemically induced*,  immunology,  pathology*
Bronchoalveolar Lavage Fluid / immunology
Chronic Disease
Eosinophil Cationic Protein / immunology,  metabolism
Eosinophils / immunology,  metabolism
Fibroblast Growth Factors / immunology,  metabolism
Inflammation / chemically induced,  immunology,  pathology
Interleukin-8 / immunology,  metabolism
Irritants / toxicity*
Lung / immunology,  metabolism,  pathology
Matrix Metalloproteinase 1 / immunology,  metabolism
Middle Aged
Neutrophils / immunology,  metabolism
Transforming Growth Factor beta1 / immunology,  metabolism
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Interleukin-8; 0/Irritants; 0/Transforming Growth Factor beta1; 62031-54-3/Fibroblast Growth Factors; EC 3.1.27.-/Eosinophil Cationic Protein; EC Metalloproteinase 1

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