Document Detail

Long-term outcomes in difficult-to-treat patients with recurrent pericarditis.
MedLine Citation:
PMID:  16828606     Owner:  NLM     Status:  MEDLINE    
Patients with many recurrences of acute pericarditis are commonly alarmed by the fear of constriction. We studied their long-term outcome and the possible presence of systemic diseases. Sixty-one Italian patients (36 men) were followed for an average of 8.3 years according to a predefined protocol, including testing for autoimmune diseases and familial Mediterranean fever. Symptomatic pericarditis lasted from 1 to 43 years (mean 5.4 years). Fifty-two patients had been referred to us after failure of previous therapies, including steroids. We observed 378 attacks with a mean of 1.6 per patient per year and 156 hospital admissions. Thirteen patients had a post-cardiac injury syndrome. In 43 (70.5%), the pericarditis remained idiopathic, whereas we made a new diagnosis of rheumatoid arthritis in 1 and of Sjogren's syndrome in 4 patients, but in these patients pericarditis represented the dominant clinical manifestation. Cardiac tamponade occurred during the initial attacks in 4 patients (6.5%) but never recurred. Pleural effusions were present during the first attack in 22 patients (36.0%) and liver involvement in 5 (8%). No patients developed constrictive pericarditis. Echocardiographic examination produced no evidence of chronic myocardial disease. Response to therapy was good. Thirty-one patients (50.8%) are in sustained remission, without any therapy; their total observation period has averaged 10.3 years. In idiopathic patients, antinuclear antibodies were present in 56.2% and anti-Ro/SSA in 8.3%. Mutations linked to familial Mediterranean fever were absent. In conclusion, in this large series of difficult patients with recurrent acute pericarditis and a very long follow-up, the long-term prognosis is good.
Antonio Brucato; Giovanni Brambilla; Antonella Moreo; Antonella Alberti; Carlotta Munforti; Anna Ghirardello; Andrea Doria; Yael Shinar; Avi Livneh; Yehuda Adler; Yehuda Shoenfeld; Francesco Mauri; Giancarlo Palmieri; David H Spodick
Related Documents :
7224356 - Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical s...
1791016 - Fiberoptic bronchoscopy in patients with haemoptysis and normal chest roentgenograms.
17143816 - Patients with previously treated tuberculosis no longer neglected.
20419526 - Pericardial effusions in adolescent girls with anorexia nervosa: clinical course and ri...
21475956 - Variability of plasma homovanillic acid over 13 months in patients with schizophrenia; ...
20725736 - Nocturia is an independent predictor of severe obstructive sleep apnea in patients with...
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-06-05
Journal Detail:
Title:  The American journal of cardiology     Volume:  98     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  AIM; IM    
Department of Internal Medicine, Ospedale Niguarda, Milano, Department of Rheumatology, University of Padua, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Antibodies, Antinuclear / analysis
Diagnosis, Differential
Drug Therapy, Combination
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
Glucocorticoids / therapeutic use*
Middle Aged
Pericarditis / diagnosis,  drug therapy*
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antibodies, Antinuclear; 0/Glucocorticoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Pregnancy after biventricular repair for pulmonary atresia with ventricular septal defect.
Next Document:  Effect of exercise on frequency of stent fracture in the superficial femoral artery.