| Long-term outcomes of children treated with the ketogenic diet in the past. | |
| | |
MedLine Citation:
|
PMID: 20132287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: The ketogenic diet has well-established short- and long-term outcomes for children with intractable epilepsy, but only for those actively receiving it. However, no information exists about its long-term effects years after it has been discontinued. METHODS: Living subjects were identified who were treated at the Johns Hopkins Hospital with the ketogenic diet from November 1993 to December 2008 for >or=1 month, and had discontinued it >or=6 months prior to this study. Of 530 patients who were eligible, 254 were successfully contacted by phone or e-mail with a survey and request for laboratory studies. RESULTS: Questionnaires were completed by 101 patients, with a median current age of 13 years (range 2-26 years). Median time since discontinuing the ketogenic diet was 6 years (range 0.8-14 years). Few (8%) still preferred to eat high fat foods. In comparison to the 52% responder rate (>50% seizure reduction) at ketogenic diet discontinuation, 79% were now similarly improved (p = 0.0001). Ninety-six percent would recommend the ketogenic diet to others, yet only 54% would have started it before trying anticonvulsants. Lipids were normal (mean total cholesterol 158 mg/dl), despite most being abnormal while on the ketogenic diet. The mean Z scores for those younger than age 18 years were -1.28 for height and -0.79 for weight. In those 18 years of age or older, the mean body mass index (BMI) was 22.2. DISCUSSION: This is the first study to report on the long-term effects of the ketogenic diet after discontinuation. The majority of subjects are currently doing well with regard to health and seizure control. |
| | |
Authors:
|
Amisha Patel; Paula L Pyzik; Zahava Turner; James E Rubenstein; Eric H Kossoff |
Related Documents
:
|
17241227 - Discontinuing the ketogenic diet in seizure-free children: recurrence and risk factors. 19332337 - Ketogenic diets: evidence for short- and long-term efficacy. 3170777 - Slow and incomplete histological and functional recovery in adult gluten sensitive ente... 17150447 - Diet therapy in refractory pediatric epilepsy: increased efficacy and tolerability. 6511167 - Body size, subcutaneous fatness and total body fat in older adults. 12840187 - High dietary fat promotes syndrome x in nonobese rats. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-01 |
Journal Detail:
|
Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-07-19 Completed Date: 2010-08-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
|
Languages: eng Pagination: 1277-82 Citation Subset: IM |
Affiliation:
|
Johns Hopkins University, Baltimore, Maryland, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Child Child, Preschool Cognition* / physiology Epilepsy / blood, diet therapy*, psychology* Female Humans Ketogenic Diet / trends* Lipids / blood Male Prospective Studies Questionnaires Time Factors Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
M01-RR00052/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interictal cerebral blood flow abnormality in cryptogenic West syndrome.
Next Document: Impact of severe epilepsy on development: Recovery potential after successful early epilepsy surgery...