Document Detail

Long-term outcome (up to 15 years) of balloon angioplasty of discrete native coarctation of the aorta in adolescents and adults.
MedLine Citation:
PMID:  15028367     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study evaluated the long-term follow-up results of balloon angioplasty (BA) in adolescent and adult patients with discrete coarctation of the aorta. BACKGROUND: Although the immediate and intermediate term results of BA for patients with aortic coarctation (AC) have been encouraging, there is a paucity of data on long-term follow-up results. METHODS: This basis of this study was follow-up of 49 patients (mean age, 22 +/- 7 years) undergoing BA for discrete AC at median interval of 10.2 years, including cardiac catheterization, magnetic resonance imaging, and Doppler echocardiography. RESULTS: No early or late deaths occurred. Balloon angioplasty produced a reduction in peak AC gradient from 66 +/- 23 mm Hg (95% confidence interval [CI]: 59.5 to 72.7) to 10.8 +/- 7 mm Hg (95% CI: 8.8 to 12.5) (p < 0.0001). Follow-up catheterization 12 months later revealed a residual gradient of 6.2 +/- 6 mm Hg (95% CI: 4.4 to 7.9) (p < 0.001). Four patients (7.5%) with suboptimal initial outcome with peak gradient >20 mm Hg had successful repeat angioplasty. Aneurysm developed at the site of dilation in four patients (7.5%). Magnetic resonance imaging follow-up results revealed no new aneurysm or appreciable changes in the size of pre-existing aneurysms, and no recoarctation was observed. Also, no appreciable changes in the Doppler gradient across the AC site were noted. The blood pressure had normalized without medication in 31 (63%) of the 49 patients. CONCLUSIONS: Long-term results of BA for discrete AC are excellent and should be considered as first option for treatment of this disease.
Mohamed Eid Fawzy; Mahmoud Awad; Walid Hassan; Yusuf Al Kadhi; Mohamed Shoukri; Fadel Fadley
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  43     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-18     Completed Date:  2004-04-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1062-7     Citation Subset:  AIM; IM    
Department of Cardiovascular Diseases (MBC-16), King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia.
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MeSH Terms
Angioplasty, Balloon*
Aortic Coarctation / pathology,  radiography,  therapy*
Blood Pressure
Follow-Up Studies
Magnetic Resonance Imaging
Middle Aged
Severity of Illness Index
Treatment Outcome

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