Document Detail

Long-term outcome of tandem stenting for stenoses of the intracranial vertebrobasilar artery and vertebral ostium.
MedLine Citation:
PMID:  19279273     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Patients with symptomatic atherosclerotic stenosis of the intracranial vertebrobasilar artery (VBA) have a poor prognosis, and those with coexistent intracranial and extracranial stenoses have worse outcomes despite medical therapy. Our aim was to study the long-term outcome of patients with symptomatic atherosclerotic tandem stenoses at the intracranial VBA and the vertebral artery ostium (VAO) after elective stent placement. MATERIALS AND METHODS: Ten consecutive patients (mean age, 65.3 years) with this condition underwent elective stent placement at our institution between September 2001 and December 2007. Technical success was defined as stent placement of both VAO and intracranial VBA stenoses with complete stent coverage of the lesions, residual stenosis of < or = 30%, and good antegrade blood flow. The study end point was a composite of any stroke or death within 30 days and ischemic stroke in the VBA territory after 30 days. RESULTS: Technical success was obtained in 9 of 10 patients without any stroke or death within 30 days. During a median follow-up duration of 32 months, 1 patient had a fatal ischemic stroke in the VBA territory at 4 months, and the other 9 patients were free from stroke recurrence. Thus, the annual stroke rate in VBA territory (including any stroke or death within 30 days) was 3.8%. CONCLUSIONS: This pilot study shows that elective stent placement for patients with symptomatic atherosclerotic tandem stenoses at the intracranial VBA and VAO has an acceptable long-term outcome and may be considered as an alternative to medical therapy.
B Du; E H C Wong; W-J Jiang
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-11
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  30     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  840-4     Citation Subset:  IM    
Department of Neurology and Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
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MeSH Terms
Angioplasty, Balloon / methods*
Cerebral Angiography
Cerebrovascular Circulation
Follow-Up Studies
Intracranial Arteriosclerosis / radiography,  therapy*
Middle Aged
Pilot Projects
Treatment Outcome
Vertebral Artery / radiography
Vertebrobasilar Insufficiency / radiography,  therapy*

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