Document Detail

Long-term outcome of patients with distal ulcerative colitis and inflammation of the appendiceal orifice.
MedLine Citation:
PMID:  22187699     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND AIMS: Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC.
METHODS: Patients with UC-IAO were identified from the local IBD database. Disease outcome and therapeutic requirements during follow-up were accurately collected, and compared with a control group of patients with distal UC without peri-appendiceal involvement matched by disease extent (proctitis/distal), smoking habit, and date and age at diagnosis.
RESULTS: Fourteen UC patients were found to have UC-IAO, most of them with initial extent of UC limited to the rectum. All patients were initially managed with mesalazine administered orally (28.5%), topically (28.5%), or in combination (43%). After a median follow-up of 78 months (interquartile range - IQR 45-123) most UC-IAO patients were successfully managed with oral and/or topical aminosalicylates. Only one of them developed proximal disease progression. As compared to controls, no differences in clinical outcomes or therapeutic requirements were found.
CONCLUSIONS: Patients with UC-IAO tend to present a mild course, with a low probability to develop proximal progression of disease extent or to require immunosuppressive therapy or colectomy.
Juan E Naves; Vicente Lorenzo-Zuniga; Laura Marín; Míriam Manosa; Blanca Oller; Vicente Moreno; Yamile Zabana; Jaume Boix; Eduard Cabré; Eugeni Domenech
Related Documents :
9464299 - Short-pulse carbon dioxide laser resurfacing in the treatment of rhytides and scars. a ...
4010419 - Complications of laser surgery for laryngeal papillomatosis.
6472029 - Treatment of condyloma acuminata with carbon dioxide laser: a prospective study.
7496669 - Skin resurfacing with the ultrapulse carbon dioxide laser. observations on 100 patients.
25095309 - Cryotherapy effect on oral mucositis severity among recipients of bone marrowtransplant...
21109079 - Minimally invasive video-assisted thyroidectomy versus conventional thyroidectomy: a co...
12125499 - Long-term effect of tcm decoctions in treatment of nephrotic syndrome.
24186469 - Modular versus nonmodular neck femoral implants in primary total hip arthroplasty: whic...
4056869 - Astrocytomas of the spinal cord in children and adolescents.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal and liver diseases : JGLD     Volume:  20     ISSN:  1842-1121     ISO Abbreviation:  J Gastrointestin Liver Dis     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101272825     Medline TA:  J Gastrointestin Liver Dis     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  IM    
Germans Trias i Pujol University Hospital, Centro de Investigación Biomédica en red en Enfermedades Hepatica y Digestivas, Badalona, Spain; Email:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Performance of routine Helicobacter pylori tests in patients with atrophic gastritis.
Next Document:  Response to first intravenous steroid therapy determines the subsequent risk of colectomy in ulcerat...