| Long-term outcome of patients with distal ulcerative colitis and inflammation of the appendiceal orifice. | |
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MedLine Citation:
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PMID: 22187699 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Skip inflammation of the appendiceal orifice has been described in distal UC (UC-IAO) but long-term clinical outcomes are poorly established. Our aim was to evaluate the long-term clinical outcomes of UC-IAO as compared to classic distal UC. METHODS: Patients with UC-IAO were identified from the local IBD database. Disease outcome and therapeutic requirements during follow-up were accurately collected, and compared with a control group of patients with distal UC without peri-appendiceal involvement matched by disease extent (proctitis/distal), smoking habit, and date and age at diagnosis. RESULTS: Fourteen UC patients were found to have UC-IAO, most of them with initial extent of UC limited to the rectum. All patients were initially managed with mesalazine administered orally (28.5%), topically (28.5%), or in combination (43%). After a median follow-up of 78 months (interquartile range - IQR 45-123) most UC-IAO patients were successfully managed with oral and/or topical aminosalicylates. Only one of them developed proximal disease progression. As compared to controls, no differences in clinical outcomes or therapeutic requirements were found. CONCLUSIONS: Patients with UC-IAO tend to present a mild course, with a low probability to develop proximal progression of disease extent or to require immunosuppressive therapy or colectomy. |
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Authors:
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Juan E Naves; Vicente Lorenzo-Zuniga; Laura Marín; Míriam Manosa; Blanca Oller; Vicente Moreno; Yamile Zabana; Jaume Boix; Eduard Cabré; Eugeni Domenech |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastrointestinal and liver diseases : JGLD Volume: 20 ISSN: 1842-1121 ISO Abbreviation: J Gastrointestin Liver Dis Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101272825 Medline TA: J Gastrointestin Liver Dis Country: Romania |
Other Details:
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Languages: eng Pagination: 355-8 Citation Subset: IM |
Affiliation:
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Germans Trias i Pujol University Hospital, Centro de Investigación Biomédica en red en Enfermedades Hepatica y Digestivas, Badalona, Spain; Email: edomenech.germanstrias@gencat.cat. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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