Document Detail

Long-term outcome of non-fistulizing (ulcers, stricture) perianal Crohn's disease in patients treated with infliximab.
MedLine Citation:
PMID:  19583709     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In Crohn's disease, anal ulcers and stricture can be disabling. AIM: To evaluate long-term outcome of non-fistulizing perianal Crohn's disease under infliximab. METHODS: The medical records of 99 patients with non-fistulizing perianal Crohn's disease at first infliximab infusion were reviewed. Complete responses (ulcer healing or stricture regression) after induction infliximab therapy and at the maximal follow-up were assessed. RESULTS: Ninety-four patients (94.9%) had ulcers, 22 (22.2%) had stricture and 31 (31.3%) had draining perianal fistulas at first infliximab infusion. After infliximab induction therapy, 40/94 (42.5%) patients with ulcers, 4/22 (18.2%) with stricture and 10/31 (32.2%) with fistulas had a complete response. Eight patients were lost to follow-up. After a median follow-up of 175 weeks (range, 13-459), complete response rates for ulcers, stricture and fistulas were 72.3% (68/94), 54.5% (12/22) and 54.8% (20/31) respectively. Long-term response for cavitating ulcer was positively associated with concomitant immunosuppressant use (P = 0.017) and older age (P = 0.049). Among the 12 patients with complete regression of stricture, 6 patients also had anal dilatation. Complete response was associated with perianal pain relief and disappearance of soiling. Three patients with ulcers developed an anal abscess. CONCLUSIONS: Infliximab therapy may be effective in inducing and maintaining response for ulcers.
G Bouguen; I Trouilloud; L Siproudhis; A Oussalah; M-A Bigard; J-F Bretagne; L Peyrin-Biroulet
Related Documents :
11782699 - Sclerosants in microfoam. a new approach in angiology.
20479909 - A matched case-control study of a novel acid-pump antagonist and proton-pump inhibitor ...
8527619 - Double-blind, randomized trial of roxatidine 150 mg in the early evening versus bedtime...
17067979 - Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a pro...
19583709 - Long-term outcome of non-fistulizing (ulcers, stricture) perianal crohn's disease in pa...
8018979 - Nizatidine in the treatment of acute gastric ulcer: a multicenter trial.
10587029 - Endoscopic treatment of carpet-like adenomas of the rectum.
16152989 - Combination of immunosuppressive agents in treatment of steroid-resistant minimal chang...
10431869 - Surgery for atrial fibrillation using radiofrequency catheter ablation: assessment of r...
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-07-06
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  30     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-08     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  749-56     Citation Subset:  IM    
Department of Hepato-Gastroenterology, University Hospital of Rennes, Pontchaillou, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / adverse effects,  therapeutic use*
Constriction, Pathologic
Crohn Disease / complications,  drug therapy*
Dose-Response Relationship, Drug
Drug Evaluation
Fissure in Ano / drug therapy*,  etiology
Gastrointestinal Agents / adverse effects,  therapeutic use*
Long-Term Care
Middle Aged
Rectal Fistula / drug therapy*,  etiology
Time Factors
Treatment Outcome
Wound Healing
Young Adult
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Gastrointestinal Agents; 0/infliximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Thiopental pharmacokinetics in newborn infants: a case report of overdose.
Next Document:  Antinociceptive activity of a new benzofuranone derived from a chalcone.