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Long-term outcome of low-activity radioiodine administration preceded by adjuvant recombinant human TSH pretreatment in elderly subjects with multinodular goiter.
MedLine Citation:
PMID:  19566933     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Large multinodular goiter (MNG) in elderly people is a common finding which can require intervention. The long-term effect of radioiodine therapy on thyroid volume (TV) and function after recombinant human (rh) TSH pre-treatment was evaluated.
METHODS: After baseline evaluation, 40 subjects over 60 years old with a large MNG were treated with 131I up to the activity of 600 MBq. Nineteen patients were pretreated with rhTSH (0.1 mg on 2 consecutive days; group 1) while 21 subjects underwent treatment without rhTSH pretreatment (group 2). TV was monitored every 6-12 months by ultrasonography. The median follow-up period was 36 months.
RESULTS: At the baseline, the groups matched in terms of TV, 24-h radioiodine uptake (RAIU), urinary iodine and neck complaints. The number of subjects pretreated with anti-thyroid drugs was significantly (P = 0.01) greater in group 2 than in group 1; TSH was more suppressed (P = 0.003) and f-T3 was more elevated (P = 0.005) in group 2 than in group 1 patients. RhTSH increased 24-h RAIU in group 1 up to the baseline level observed in group 2. The 131I activity administered was similar in both groups. Adverse events were slight and similar in both groups. A permanent post-radioiodine toxic condition was reported only in 2 patients in group 2. After radioiodine therapy, hypothyroidism was observed in significantly more group 1 patients than group 2 patients (P = 0.002). While TV was reduced in both groups, the percentage TV reduction recorded at the last examination was significantly higher (P = 0.03) in group 1 than in group 2. MNG-related complaints were significantly reduced in both group 1 (P = 0.0001 vs baseline) and group 2 (P = 0.001) patients.
CONCLUSION: Low radioiodine activities after pretreatment with low-dosage rhTSH are able to reduce TV and improve MNG-related symptoms in elderly subjects.
Authors:
Massimo Giusti; Mauro Caputo; Iolanda Calamia; Mariaclaudia Bagnara; Enrica Ceresola; Mara Schiavo; Michele Mussap; Diego Ferone; Francesco Minuto; Marcello Bagnasco
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Publication Detail:
Type:  Journal Article     Date:  2009-06-30
Journal Detail:
Title:  Thyroid research     Volume:  2     ISSN:  1756-6614     ISO Abbreviation:  Thyroid Res     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-21     Completed Date:  2011-07-14     Revised Date:  2011-11-21    
Medline Journal Info:
Nlm Unique ID:  101469037     Medline TA:  Thyroid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  6     Citation Subset:  -    
Affiliation:
Clinica Endocrinologica, Azienda Ospedaliera Universitaria "San Martino", Genoa, Italy. magius@unige.it.
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