Document Detail


Long-term outcome of infants with twin-to-twin transfusion syndrome.
MedLine Citation:
PMID:  17003558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To clarify the long-term neurodevelopmental outcome of twin-to-twin transfusion syndrome (TTTS) survivors. METHODS: From January 1994 to December 2003, 33 newborns with TTTS who were derived from 18 monochorionic twin gestations were enrolled for the study. The development and growth at 3 or 6 years of age were compared between TTTS survivors and weight-matched singleton controls. RESULTS: The mortality in TTTS (8/33: 24%) was significantly higher than that of the controls (7/80: 9%). Of all 12 TTTS patients who were diagnosed before 25 weeks and born before 28 weeks of gestation, in 10 (83%) it led to neonatal or intrauterine death. The morbidity of cerebral palsy, epilepsy, and mental retardation did not differ between TTTS and control patients. The morbidity and severity of neurological deficits at school age were similar in both groups. No growth parameters at 3 or 6 years of age differed between TTTS and controls. CONCLUSIONS: Morbidity, growth and development of TTTS survivors attained comparable levels of weight-matched controls, despite the higher neonatal mortality. These results suggest that the early management of TTTS is critical for refining the total outcome of the affected twins.
Authors:
Shunji Hikino; Shouichi Ohga; Takashi Kanda; Toshinori Nakashima; Junko Yamamoto; Hideki Nakayama; Hitoo Nakano; Toshiro Hara
Related Documents :
1789918 - Stuck twin with cotwin nonimmune hydrops: successful treatment by amniocentesis.
3799768 - Randomized management of the second nonvertex twin: vaginal delivery or cesarean section.
17881218 - Vaginal twin delivery: a survey and review of location, anesthesia coverage and interve...
16580878 - Positional differences in fitness and anthropometric characteristics in australian foot...
2733058 - Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in vietnam veterans o...
23401418 - Increased lung volume in infants and toddlers at high compared to low altitude.
Publication Detail:
Type:  Journal Article     Date:  2006-09-22
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  22     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2006-12-28     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Affiliation:
Perinatal and Maternity Care Unit, Kyushu University Hospital, Fukuoka, Japan. hikino@pediatr.med.kyushu-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Child Development / physiology*
Female
Fetofetal Transfusion / mortality,  physiopathology*
Growth / physiology*
Humans
Infant, Newborn
Intelligence / physiology
Longitudinal Studies
Nervous System / growth & development
Pregnancy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Parvovirus B19 infection in pregnancy studied by maternal viral load and immune responses.
Next Document:  Amniotic band syndrome with limb amputation after exposure to mifepristone in early pregnancy.