Document Detail

Long-term outcome of infants with twin-to-twin transfusion syndrome.
MedLine Citation:
PMID:  17003558     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To clarify the long-term neurodevelopmental outcome of twin-to-twin transfusion syndrome (TTTS) survivors. METHODS: From January 1994 to December 2003, 33 newborns with TTTS who were derived from 18 monochorionic twin gestations were enrolled for the study. The development and growth at 3 or 6 years of age were compared between TTTS survivors and weight-matched singleton controls. RESULTS: The mortality in TTTS (8/33: 24%) was significantly higher than that of the controls (7/80: 9%). Of all 12 TTTS patients who were diagnosed before 25 weeks and born before 28 weeks of gestation, in 10 (83%) it led to neonatal or intrauterine death. The morbidity of cerebral palsy, epilepsy, and mental retardation did not differ between TTTS and control patients. The morbidity and severity of neurological deficits at school age were similar in both groups. No growth parameters at 3 or 6 years of age differed between TTTS and controls. CONCLUSIONS: Morbidity, growth and development of TTTS survivors attained comparable levels of weight-matched controls, despite the higher neonatal mortality. These results suggest that the early management of TTTS is critical for refining the total outcome of the affected twins.
Shunji Hikino; Shouichi Ohga; Takashi Kanda; Toshinori Nakashima; Junko Yamamoto; Hideki Nakayama; Hitoo Nakano; Toshiro Hara
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Publication Detail:
Type:  Journal Article     Date:  2006-09-22
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  22     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2007  
Date Detail:
Created Date:  2006-12-28     Completed Date:  2007-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Perinatal and Maternity Care Unit, Kyushu University Hospital, Fukuoka, Japan.
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MeSH Terms
Child Development / physiology*
Fetofetal Transfusion / mortality,  physiopathology*
Growth / physiology*
Infant, Newborn
Intelligence / physiology
Longitudinal Studies
Nervous System / growth & development

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