Document Detail

Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study.
MedLine Citation:
PMID:  18339730     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP), alone or in combination (CIP/CIM), are frequent complications in patients in the intensive care unit (ICU). There is no evidence that differentiating between CIP and CIM has any impact on patient prognosis. METHODS: 1-year prospective cohort study of patients developing CIP, CIM or combined CIP and CIM during ICU stay. RESULTS: 28 out of 92 (30.4%) patients developed electrophysiological signs of CIP and/or CIM during their ICU stay, which persisted in 18 patients at ICU discharge. At hospital discharge, diagnoses in the 15 survivors were CIM in six cases, CIP in four, combined CIP and CIM in three and undetermined in two uncooperative patients. During the 1-year follow-up of six patients with CIM, one patient died and five recovered completely within 3 (three patients) to 6 (two patients) months. Of three patients with CIP/CIM, one died, one recovered and one with residual CIP remained tetraplegic. Of four patients with CIP, one recovered, two had persisting muscle weakness and one remained tetraparetic. CONCLUSION: CIM has a better prognosis than CIP. Differential diagnosis is important to predict long-term outcome in ICU patients.
B Guarneri; G Bertolini; N Latronico
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2008-03-13
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  79     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  838-41     Citation Subset:  IM    
Department of Neuroscience, Section of Clinical Neurophysiology, University of Brescia, Spedali Civili, Italy.
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MeSH Terms
Critical Care*
Diagnosis, Differential
Follow-Up Studies
Length of Stay
Middle Aged
Muscular Diseases / diagnosis*,  therapy
Polyneuropathies / diagnosis*,  therapy
Recovery of Function
Time Factors
Treatment Outcome

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