Document Detail


Long-term outcome after resection of non-small cell lung carcinoma complicated by pneumoconiosis.
MedLine Citation:
PMID:  16998679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Lung cancer resection in patients with respiratory complications is associated with a high surgical risk and the operative indications are usually serious. Consequently, the long-term results are unclear. We aimed to clarify the validity of surgery for non-small cell lung cancer (NSCLC) in patients with pneumoconiosis. METHODS: We reviewed the clinical and pathological data of 122 patients undergoing resection of NSCLC with pneumoconiosis (n = 34: group A) or without pneumoconiosis (n = 88: group B) to assess treatment outcomes and prognostic factors. RESULTS: Among the treatment factors, intraoperative blood loss was significantly greater in group A (723.2 +/- 647.3 ml) than in group B (466.4 +/- 450.7 ml) (P = 0.0067), although the operative times (207 +/- 103.4 min vs 196.1 +/- 53.5 min, respectively) and postoperative drainage period (8.3 +/- 4.2 days vs 8.5 +/- 5.7 days, respectively) did not differ significantly between the two groups (P = 0.9466 and P = 0.6355, respectively). Among the postoperative complications, the incidence of hemorrhage was significantly higher in group A (29.4%) than in group B (7.9%) (P = 0.0022). The 5-year survival rates did not differ significantly between the two groups, (45.9% and 55.7% for groups A and B respectively) (P = 0.9424). CONCLUSIONS: The coexistence of pneumoconiosis does not adversely affect postoperative survival or the treatment of NSCLC, although it is associated with increased intraoperative blood loss and postoperative hemorrhage. Thus, if precautions are taken to minimize hemorrhage, surgery cannot be excluded as a treatment option for NSCLC in patients with pneumoconiosis.
Authors:
Yuma Ebihara; Yutaka Makino; Masaki Miyamoto; Masahito Hashimoto; Satoshi Kondo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  36     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  869-73     Citation Subset:  IM    
Affiliation:
Departments of Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060-8638, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung / complications,  pathology,  surgery*
Female
Follow-Up Studies
Humans
Incidence
Lung Neoplasms / complications,  pathology,  surgery*
Male
Middle Aged
Pneumoconiosis / epidemiology,  etiology*
Pneumonectomy*
Postoperative Complications
Prognosis
Retrospective Studies
Survival Rate
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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