Document Detail


Long-term outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a single institution experience.
MedLine Citation:
PMID:  19272789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) is the first treatment of choice with good short-term results. Only limited data are available concerning the long-term outcome after PEA. The purpose of this study is to evaluate the long-term survival and functional outcome after PEA with nearly 10 years experience. METHOD: In the period of December 1998 and December 2007 120 patients with CTEPH were referred to the St Antonius Hospital (Nieuwegein, The Netherlands) of whom 72 underwent PEA. The clinical data are collected retrospectively. RESULTS: In-hospital mortality was (5/72) 6.9%. Since 2004 one patient died in the hospital (1/38, 2.9%). Two patients died during long-term follow-up with a median observation of 3 years. The overall 1-, 3- and 5-year survival rates were 93.1%, 91.2% and 88.7% respectively. Prior to surgery patients were in New York Heart Association functional class III (58) and IV (14) with a mean pulmonary vascular resistance of 572+/-313 dynes s cm(-5). The following data were compared before and after operation: mean pulmonary artery pressure (mPAP) decreased from 42+/-11 to 22+/-7 mmHg (p=0.0001), NT-pro BNP improved from 1527+/-1652 to 160+/-3 pg/ml (p=0.0001), 6 min walk distance (6MWD) from 359+/-124 to 518+/-11 m (p=0.0001), and almost all patients returned to functional class I or II (p=0.0001). CONCLUSION: Pulmonary endarterectomy for patients with CTEPH has shown a dramatic improvement of clinical status with excellent long-term survival.
Authors:
Nabil Saouti; Wim J Morshuis; Robin H Heijmen; Repke J Snijder
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-09
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  35     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  947-52; discussion 952     Citation Subset:  IM    
Affiliation:
Department of Cardio-Thoracic Surgery, St Antonius Hospital, Koekoekslaan 1, Nieuwegein 3435 CM, The Netherlands. nabilio25@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Chronic Disease
Endarterectomy / methods*
Epidemiologic Methods
Female
Humans
Hypertension, Pulmonary / etiology,  physiopathology,  surgery*
Male
Middle Aged
Pulmonary Artery / physiopathology,  surgery*
Pulmonary Embolism / complications
Thromboembolism / complications*
Treatment Outcome
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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