Document Detail

Long-term outcome of acute myocardial infarction patients treated with stents versus balloon angioplasty: results from randomized trials.
MedLine Citation:
PMID:  18353468     Owner:  NLM     Status:  MEDLINE    
AIM: To examine the impact of primary stent implantation versus balloon angioplasty on long-term outcome (median 8 years) in 117 patients with ST-elevation myocardial infarction (STEMI) from randomized trials. METHODS: Enrolled patients were those presenting with STEMI within 12 h of symptom onset. Patients were randomized to either Palmaz-Schatz stent implantation (N=25) or balloon angioplasty (N=23) between January and November 1996; or Palmaz-Schatz (N=26), or Cordis coil stent implantation (N=24) or balloon angioplasty (N=19) between February 1998 and March 1999. RESULTS: Patients (67+/-11 years) arrived to the hospital within median 2.5 h of symptom onset with Killip 1/2/3/4 grade (72/19/7/2%, respectively). The culprit lesion was located in the left anterior descending (50%), right (39%), or left circumflex coronary artery (11%) with TIMI 0/1/2/3 flow (81/5/12/2%, respectively). Clinical/angiographic features were comparable between the 2 groups. During follow-up, there was a significant reduction in cardiac mortality in the stent group (5%) compared to the angioplasty group (17%, log-rank test p=0.04). In addition, the stent group had a lower target lesion revascularization rate (28% versus 52%, p=0.008), and a significantly lower major adverse cardiac event rate (37% versus 67%, p=0.005), than the angioplasty group. CONCLUSION: Compared to balloon angioplasty, primary stenting resulted in a sustained beneficial effect on cardiac mortality at 8 years.
Hideaki Kaneda; Yoshitaka Hiroe; Shinji Tanaka; Takaaki Shiono; Hideko Inaba; Yusuke Miyashita; Saeko Takahashi; Yoshio Taketani; Hiroshi Domae; Junya Matsumi; Shigeru Saito
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2008-03-18
Journal Detail:
Title:  International journal of cardiology     Volume:  133     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-07-23     Revised Date:  2010-09-17    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, 1202-1 Yamazaki, Kamakura 247-8533, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Middle Aged
Myocardial Infarction / mortality,  therapy*
Time Factors
Treatment Outcome
Comment In:
Int J Cardiol. 2010 Sep 3;143(3):446-7   [PMID:  19108917 ]

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