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Long term outcome of acquired food allergy in pediatric liver recipients: a single center experience.
MedLine Citation:
PMID:  22690312     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Food induced sensitization has been reported in pediatric liver recipients. However long term follow up has not been established so far.We report here our experience regarding 3 pediatric patients who developed acquired food allergy after liver transplantation. The first patient suffered from persistent diarrhea and eczema. The second one presented with abdominal pain with no signs of rejection, abdominal discomfort, vomiting when ingesting milk proteins and responded well to the elimination diet. The third patient presented with facial angioedema and hoarseness of voice. She had multiple food allergies and reacted to milk, egg and sesame. All the patients had elevated total Immunoglobulin E (IgE) and elevated specific IgE antibodies to the implicated food allergens. The first patient presented clinical manifestations of allergy when she was 19 months old. The second patient became allergic at the age of 16 and the third patient at the age of 3. The symptoms of food allergy persisted for 8 years in the first case and for 2 years in the other two cases. Low levels of specific IgE antibodies to the implicated food allergens and an enhanced T-helper 1 cell immune response toward interferon-gamma production were markers of tolerance acquisition. The long term prognosis in our cases was excellent. Food allergy resolved in all the patients. The long term prognosis of acquired food allergy after liver transplantation is currently obscure. More studies would be needed including greater number of patients to determine whether acquired food allergy is transient in pediatric liver recipients.
Authors:
Antigoni Mavroudi; Ioannis Xinias; Aristidis Deligiannidis; Efthimia Parapanissiou; George Imvrios
Publication Detail:
Type:  Journal Article     Date:  2012-01-30
Journal Detail:
Title:  Pediatric reports     Volume:  4     ISSN:  2036-7503     ISO Abbreviation:  Pediatr Rep     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101551542     Medline TA:  Pediatr Rep     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  e6     Citation Subset:  -    
Affiliation:
Third Pediatric Department.
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