| Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. | |
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MedLine Citation:
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PMID: 19880495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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T-cell immunotherapy that takes advantage of Epstein-Barr virus (EBV)-stimulated immunity has the potential to fill an important niche in targeted therapy for EBV-related cancers. To address questions of long-term efficacy, safety, and practicality, we studied 114 patients who had received infusions of EBV-specific cytotoxic T lymphocytes (CTLs) at 3 different centers to prevent or treat EBV(+) lymphoproliferative disease (LPD) arising after hematopoietic stem cell transplantation. Toxicity was minimal, consisting mainly of localized swelling at sites of responsive disease. None of the 101 patients who received CTL prophylaxis developed EBV(+) LPD, whereas 11 of 13 patients treated with CTLs for biopsy-proven or probable LPD achieved sustained complete remissions. The gene-marking component of this study enabled us to demonstrate the persistence of functional CTLs for up to 9 years. A preliminary analysis indicated that a patient-specific CTL line can be manufactured, tested, and infused for $6095, a cost that compares favorably with other modalities used in the treatment of LPD. We conclude that the CTL lines described here provide safe and effective prophylaxis or treatment for lymphoproliferative disease in transplantation recipients, and the manufacturing methodology is robust and can be transferred readily from one institution to another without loss of reproducibility. |
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Authors:
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Helen E Heslop; Karen S Slobod; Martin A Pule; Gregory A Hale; Alexandra Rousseau; Colton A Smith; Catherine M Bollard; Hao Liu; Meng-Fen Wu; Richard J Rochester; Persis J Amrolia; Julia L Hurwitz; Malcolm K Brenner; Cliona M Rooney |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-30 |
Journal Detail:
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Title: Blood Volume: 115 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-05 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
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Languages: eng Pagination: 925-35 Citation Subset: AIM; IM |
Affiliation:
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Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA. hheslop@bcm.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00058812 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adoptive Transfer / economics, methods Adult Child Child, Preschool Epstein-Barr Virus Infections / etiology, therapy*, virology Female Follow-Up Studies Hematopoietic Stem Cell Transplantation / adverse effects* Herpesvirus 4, Human / immunology* Humans Immunophenotyping Infant Lymphoma / etiology, mortality, therapy Lymphoproliferative Disorders / etiology, mortality, therapy* Male Survival Rate T-Lymphocytes, Cytotoxic / immunology*, transplantation Time Factors Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P01CA094237/CA/NCI NIH HHS; P30-CA21765/CA/NCI NIH HHS; P50CA126752/CA/NCI NIH HHS; R01CA061384/CA/NCI NIH HHS |
| Comments/Corrections | |
Comment In:
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Blood. 2010 Feb 4;115(5):920-1
[PMID:
20133473
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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