| Long-term outcome of Cavalier King Charles spaniel dogs with clinical signs associated with Chiari-like malformation and syringomyelia. | |
| | |
MedLine Citation:
|
PMID: 23100307 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The disease complex Chiari-like malformation (CM) and syringomyelia (SM) has been associated with the development of neuropathic pain (NeP), and commonly affects Cavalier King Charles spaniels (CKCS). This prospective cohort study followed 48 CKCSs with CM and/or SM and clinical signs suggestive of NeP for a period of 39 (±14.3) months from diagnosis. At the end of the study, 36 dogs were still alive; five dogs died of an unrelated or unknown cause, and seven were euthanased due to severe clinical signs suggestive of NeP. During the follow-up period, the clinical signs of scratching, facial rubbing behaviour, vocalisation and exercise ability were evaluated. Nine out of 48 dogs stopped scratching (P<0.001), but there was no statistically significant change in the number of dogs exhibiting exercise intolerance, vocalisation or facial rubbing behaviour. The overall severity of clinical signs based on a visual analogue scale (VAS) (0 mm: no clinical signs 100 mm: severe clinical signs) increased (from median 75 mm (interquartile ranges (IQR) 68-84) to 84 mm (IQR 71.5-91), P<0.001). A quarter of the dogs were static or improved. In general, the majority of the owners felt that the quality of life of their dogs was acceptable. Medical treatments received were gabapentin or pregabalin and/or intermittently, carprofen. The owner's perception of their animal's progress, and progress based on VAS, had strong positive correlation (Spearman's rank correlation (s(r)) 0.74, P<0.001). Overall, this study suggests that clinical signs suggestive of NeP progress in three-quarters of CKCSs with CM and/or SM. |
| | |
Authors:
|
I N Plessas; C Rusbridge; C J Driver; K E Chandler; A Craig; I M McGonnell; D C Brodbelt; H A Volk |
Related Documents
:
|
22890497 - Physiological, perceptual and technical responses to on-court tennis training on hard a... 14724207 - Exercise and nitric oxide prevent bubble formation: a novel approach to the prevention ... 1778897 - Effect of feeding and fasting on excess postexercise oxygen consumption. 17303477 - Insufficient ventilation as a cause of impaired pulmonary gas exchange during submaxima... 11339487 - Quadriceps concentric and eccentric exercise 2: differences in muscle strength, fatigue... 2916427 - Evaluation of electrode polarity on defibrillation efficacy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-25 |
Journal Detail:
|
Title: The Veterinary record Volume: - ISSN: 2042-7670 ISO Abbreviation: Vet. Rec. Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Detection of Clostridium perfringens type C in pig herds following disease outbreak and subsequent v...
Next Document: Clinical regressions and broad immune activation following combination therapy targeting human NKT c...