| Long-term outcome 10 years or more after restorative proctocolectomy and ileal pouch-anal anastomosis in patients with ulcerative colitis. | |
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MedLine Citation:
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PMID: 19280217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to assess quality of life (QOL) in a long-term follow-up of patients with ulcerative colitis (UC) 10 years and more after ileal pouch-anal anastomosis (IPAA) to correlate these results with pouch function and to assess the long-term pouch failure rate. METHODS: In a unicentric study, 294 consecutive patients after IPAA between 1988 and 1996 were identified from a prospective database. QOL was evaluated according to the validated Gastrointestinal Quality of Life Index (GIQLI). RESULTS: Overall median follow-up was 11.5 years. Thirty-seven patients experienced pouch failure (12.6%). The rates of ileal pouch success after 5, 10 and 15 years were 92.3%, 88.7% and 84.5%. According to the GIQLI, patients with a functioning pouch achieved a mean score of 107.8, reflecting a decrease of QOL of 10.8% compared to a healthy population. There were significant negative correlations between QOL and an age of >50 years (p < 0.05), pouchitis, perianal inflammation and increased stool frequency (p < 0.0001). CONCLUSIONS: QOL and functional results of patients with UC 10 years or more after IPAA were acceptable; however, those were reduced when compared to a healthy population. Pouch failure rate still increases up to 15.5% 15 years after IPAA. This result represents an important issue in providing patients with comprehensive preoperative information. |
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Authors:
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Christine Leowardi; Ulf Hinz; Mirjam Tariverdian; Peter Kienle; Christian Herfarth; Alexis Ulrich; Martina Kadmon |
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Publication Detail:
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Type: Journal Article Date: 2009-03-12 |
Journal Detail:
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Title: Langenbeck's archives of surgery / Deutsche Gesellschaft f?r Chirurgie Volume: 395 ISSN: 1435-2451 ISO Abbreviation: Langenbecks Arch Surg Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-01 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808285 Medline TA: Langenbecks Arch Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Christine.Leowardi@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Anal Canal / surgery Anastomosis, Surgical / methods Cohort Studies Colitis, Ulcerative / diagnosis, mortality, surgery* Colonic Pouches / adverse effects* Female Follow-Up Studies Humans Kaplan-Meiers Estimate Male Middle Aged Pouchitis / diagnosis, therapy Probability Proctocolectomy, Restorative / adverse effects, methods*, mortality Quality of Life* Questionnaires Retrospective Studies Risk Assessment Sex Factors Statistics, Nonparametric Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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