| Long-term otucome of West syndrome: a study of adults with a history of infantile spasms. | |
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MedLine Citation:
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PMID: 8603642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To our knowledge, ours is the first study to evaluate the outcome of infantile spasms (IS) in adult patients. We analyzed 214 children born between 1960 and 1976 who had been followed for 20-35 years or until death at 3 months to 30 years of age. Mortality was 31% (67 of 214 patients). Thirty-six of the surviving patients (24%) had normal (25 patients) or only slightly impaired (11 patients) intelligence as assessed by their educational abilities. Four had academic occupations. Eight were married or living unmarried with a partner. Five had healthy children. At follow-up, the EEGs of the 25 normal persons were either normal or slightly abnormal, demonstrated focal findings in 9 (36%), and had unspecific changes in 1. Focal abnormalities were not more common in patients with less good outcomes (37%). In patients with normal neurological outcomes, IS had been classified as cryptogenic only in 9 of 25 (36%) cases. Therefore, some patients with IS apparently have normal intelligence and socioeconomic status as adults, including patients whose spasms were either symptomatic or associated with focal EEG findings. |
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Authors:
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R Riikonen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 37 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-05-10 Completed Date: 1996-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 367-72 Citation Subset: IM |
Affiliation:
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Children's Hospital, University of Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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therapeutic use Adult Age of Onset Educational Status Electroencephalography / statistics & numerical data Employment Epilepsy / diagnosis, drug therapy, mortality Follow-Up Studies Humans Infant Intelligence Occupations Quality of Life Socioeconomic Factors Spasms, Infantile / diagnosis*, drug therapy, mortality Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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