Document Detail

Long-term otucome of West syndrome: a study of adults with a history of infantile spasms.
MedLine Citation:
PMID:  8603642     Owner:  NLM     Status:  MEDLINE    
To our knowledge, ours is the first study to evaluate the outcome of infantile spasms (IS) in adult patients. We analyzed 214 children born between 1960 and 1976 who had been followed for 20-35 years or until death at 3 months to 30 years of age. Mortality was 31% (67 of 214 patients). Thirty-six of the surviving patients (24%) had normal (25 patients) or only slightly impaired (11 patients) intelligence as assessed by their educational abilities. Four had academic occupations. Eight were married or living unmarried with a partner. Five had healthy children. At follow-up, the EEGs of the 25 normal persons were either normal or slightly abnormal, demonstrated focal findings in 9 (36%), and had unspecific changes in 1. Focal abnormalities were not more common in patients with less good outcomes (37%). In patients with normal neurological outcomes, IS had been classified as cryptogenic only in 9 of 25 (36%) cases. Therefore, some patients with IS apparently have normal intelligence and socioeconomic status as adults, including patients whose spasms were either symptomatic or associated with focal EEG findings.
R Riikonen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  37     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-05-10     Completed Date:  1996-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  IM    
Children's Hospital, University of Helsinki, Finland.
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MeSH Terms
Adrenocorticotropic Hormone / therapeutic use
Age of Onset
Educational Status
Electroencephalography / statistics & numerical data
Epilepsy / diagnosis,  drug therapy,  mortality
Follow-Up Studies
Quality of Life
Socioeconomic Factors
Spasms, Infantile / diagnosis*,  drug therapy,  mortality
Treatment Outcome
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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