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Long-term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: involvement of VDAC1 down-regulation.
MedLine Citation:
PMID:  25488258     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SCOPE:: This study elucidates effects of long term nutritional preconditioning by resveratrol on I/R injury and its underlying mechanisms.
METHODS AND RESULTS:: Mice were treated with resveratrol at 2.0 mg/kg.day by gastric gavages for 6 weeks. Then hearts were isolated and subjected to I/R injury in a Langendorff apparatus. Resveratrol significantly improved LVP, ±dp/dtmax and CF, decreased the LDH and CPK activity, and reduced the infarction size. Additionally, long-term oral resveratrol intake prevented mPTP opening and subsequently inhibited mitochondria-mediated apoptosis, as demonstrated by decrease of cytochrome c release, inactivation of caspase-3 and reduction of TUNEL-positive cells. Furthermore, resveratrol inhibited the up-regulation of VDAC1 expression induced by I/R injury. Local left ventricle overexpression of VDAC1 by adenovirus diminished the protective effect of resveratrol against I/R injury, indicating that VDAC1 plays an important role in resveratrol-mediated cardioprotection.
CONCLUSION:: Our data revealed that long-term oral intake of resveratrol sets nutritional preconditioning in coping with myocardial I/R injury. Strikingly, we found that resveratrol down-regulates VDAC1, leading to prevention of mPTP opening and cardiomyocyte apoptosis. This article is protected by copyright. All rights reserved.
Authors:
Zhangping Liao; Dan Liu; Lei Tang; Dong Yin; Shuhua Yin; Songqing Lai; Jianguo Yao; Ming He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-9
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  -     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-9     Completed Date:  -     Revised Date:  2014-12-10    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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